Drugs Do Not Work On Most Patients
Not surprising - watch now for all the nutria drug combos coming out to, salvage, control, propagate and, keep the drug scam alive. Already they are combining useless vaccines with other vitamin and herbs and claiming that these are even more effective than vaccines themselves. Of course the drug companies will never do talk about the efficacy of alternative products alone...
Chris Gupta
Glaxo chief: Our drugs do not work on most patients
By Steve Connor, Science Editor
08 December 2003
A senior executive with Britain's biggest drugs company has admitted that most prescription medicines do not work on most people who take them.Allen Roses, worldwide vice-president of genetics at GlaxoSmithKline (GSK), said fewer than half of the patients prescribed some of the most expensive drugs actually derived any benefit from them.
It is an open secret within the drugs industry that most of its products are ineffective in most patients but this is the first time that such a senior drugs boss has gone public. His comments come days after it emerged that the NHS drugs bill has soared by nearly 50 per cent in three years, rising by £2.3bn a year to an annual cost to the taxpayer of £7.2bn. GSK announced last week that it had 20 or more new drugs under development that could each earn the company up to $1bn (£600m) a year.
Dr Roses, an academic geneticist from Duke University in North Carolina, spoke at a recent scientific meeting in London where he cited figures on how well different classes of drugs work in real patients.
Drugs for Alzheimer's disease work in fewer than one in three patients, whereas those for cancer are only effective in a quarter of patients. Drugs for migraines, for osteoporosis, and arthritis work in about half the patients, Dr Roses said. Most drugs work in fewer than one in two patients mainly because the recipients carry genes that interfere in some way with the medicine, he said.
"The vast majority of drugs - more than 90 per cent - only work in 30 or 50 per cent of the people," Dr Roses said. "I wouldn't say that most drugs don't work. I would say that most drugs work in 30 to 50 per cent of people. Drugs out there on the market work, but they don't work in everybody."
Some industry analysts said Dr Roses's comments were reminiscent of the 1991 gaffe by Gerald Ratner, the jewellery boss, who famously said that his high street shops are successful because they sold "total crap". But others believe Dr Roses deserves credit for being honest about a little-publicised fact known to the drugs industry for many years.
"Roses is a smart guy and what he is saying will surprise the public but not his colleagues," said one industry scientist. "He is a pioneer of a new culture within the drugs business based on using genes to test for who can benefit from a particular drug."
Dr Roses has a formidable reputation in the field of "pharmacogenomics" - the application of human genetics to drug development - and his comments can be seen as an attempt to make the industry realise that its future rests on being able to target drugs to a smaller number of patients with specific genes.
The idea is to identify "responders" - people who benefit from the drug - with a simple and cheap genetic test that can be used to eliminate those non-responders who might benefit from another drug.
This goes against a marketing culture within the industry that has relied on selling as many drugs as possible to the widest number of patients - a culture that has made GSK one of the most profitable pharmaceuticals companies, but which has also meant that most of its drugs are at best useless, and even possibly dangerous, for many patients.
Dr Roses said doctors treating patients routinely applied the trial-and-error approach which says that if one drug does not work there is always another one. "I think everybody has it in their experience that multiple drugs have been used for their headache or multiple drugs have been used for their backache or whatever.
"It's in their experience, but they don't quite understand why. The reason why is because they have different susceptibilities to the effect of that drug and that's genetic," he said.
"Neither those who pay for medical care nor patients want drugs to be prescribed that do not benefit the recipient. Pharmacogenetics has the promise of removing much of the uncertainty."
Response rates
Therapeutic area: drug efficacy rate in per cent
* Alzheimer's: 30
* Analgesics (Cox-2): 80
* Asthma: 60
* Cardiac Arrythmias: 60
* Depression (SSRI): 62
* Diabetes: 57
* Hepatits C (HCV): 47
* Incontinence: 40
* Migraine (acute): 52
* Migraine (prophylaxis)50
* Oncology: 25
* Rheumatoid arthritis50
* Schizophrenia: 60
posted by Chris Gupta on Tuesday December 9 2003
updated on Saturday September 24 2005URL of this article:
http://www.newmediaexplorer.org/chris/2003/12/09/drugs_do_not_work_on_most_patients.htm
Related ArticlesArtificial Water Fluoridation: Off To A Poor Start / Fluoride Injures The Newborn
Please watch this short 5 minute video: Little Things Matter: The Impact of Toxins on the Developing Brain Toxins such as Arsenic, Lead, Mercury, Aluminum and other known and unknown chemicals, that are often above the legal limits, are deliberately added to our water to manage the disposal of toxic industrial waste chemicals under the pretense of "safe and effective" for water fluoridation mantra.Knowing and acting on the above should... [read more]
December 30, 2014 - Chris GuptaDrinking Water Fluoridation is Genotoxic & Teratogenic
This paper by Prof. Joe Cummins is a very important 5 minute delegation made to London Ontario Canada "Civic Works Committee" public participation meeting on January 25, 2012 on fluoride*. While a bit technical it is short and easy to grasp. A must read as it goes to the heart of the matter regarding the well established toxicity of fluoride which is well in all scientific circles even before water... [read more]
February 06, 2012 - Chris GuptaDemocracy At Work? - PPM On Fluoride
Here is a commentary on the recent (Jan, 25th, 2011) Public Participation Meeting (PPM) on Fluoride in the City of London, Ontario. The meeting started with a strong pro fluoride stance form the City engineer. His lack of knowledge on chemistry of the toxic wastes used to fluoridate water could embarrass even a high school student never mind his own profession. He blatantly violated his "duty to public welfare" as... [read more]
January 29, 2012 - Chris Gupta
