Simple Test may Detect Breast Cancers
Categories..."Dr. Sudhir Srivastava, chief of biomarkers research at the National Cancer Institute, said that until more research is done, ADAM 12 must be considered "a putative marker, those that are just at the discovery stage and need to be validated with proper studies."...
Of course meanwhile it's business as usual.
"Suffice it to say that one does not go about exposing the most susceptible segment of the population with more carcinogens ie X-rays from mamamograms when other alternatives are available. CG"
Extracted from: The Depths of Deceit Mammography
So typical of this profession. The fact that..."The test successfully identified 67, or 94 percent, of the cases in a control population of 46 women"... still does not seem to motivate them.
Like Dr. Srivastava, most will make excuses for his profession - stating they are conservative and very cautious yada yada only for the good of the patient: but just give them some funds (which neutrally come from vested interests) and out go their cautions and conservatism and we will be subjected to the most toxic and unsafe treatments with impunity....
..."most of these news release teasers are just there to give us the illusion of progress and serve to mostly to drum up, never ending, funding. Note the comment "...but he said that commercial use is probably a few years off." meanwhile give us more funds"...
Extracted from: Drano' for arteries works in 6 weeks
Urine and blood tests are not new but continually are overlooked at the expense of our health in favour of the more profitable poorer tests such as mammography and invasive dangerous biopsies
..."In his brilliantly researched 1974 book World Without Cancer, researcher and author G. Edward Griffin explains the trophoblastic theory of cancer proposed by Professor John Beard of Edinburgh University, which states that certain pre-embryonic cells in pregnancy differ in no discernible way from highly-malignant cancer cells. Edwards Griffin continues:
"The trophoblast in pregnancy indeed does exhibit all the classical characteristics of cancer. It spreads and multiplies rapidly as it eats its way into the uterus wall preparing a place where the embryo can attach itself for maternal protection and nourishment."
The trophoblast is formed in a chain reaction by another cell that Griffin simplifies down to the 'total life' cell, which has the total capacity to evolve into any organ or tissue, or a complete embryo. When the total life cell is triggered into producing trophoblast by contact with the hormone estrogen, present in both males and females, one of two different things happens. In the case of pregnancy the result is conventional development of a placenta and umbilical cord. If the trophoblast is triggered as part of a healing process however, the result is cancer or, as Edward Griffin cautions: "To be more accurate, we should say it is cancer if the healing process is not terminated upon completion of its task."
Stunning proof of this claim is readily available. All trophoblast cells produce a unique hormone called the chorionic gonadotrophic (CGH) which is easily detected in urine. Thus if a person is either pregnant or has cancer, a simple CGH pregnancy test should confirm either or both. It does, with an accuracy of better than 92% in all cases. If the urine sample shows positive it means either normal pregnancy or abnormal malignant cancer. Griffin notes: "If the patient is a woman, she either is pregnant or has cancer. If he is a man, cancer can be the only cause." So why all of the expensive, dangerous biopsies carried to 'detect' cancerous growths? One can only assume that Medicare pays doctors a larger fee for biopsies than pregnancy tests.
The above book is a must read when it comes to nutrition and cause of metabolic diseases."...
Extracted from: Politics in Healing : The Suppression & Manipulation of American Medicine
For a blood test see: The AMAS Test For Early Detection and Monitoring of Cancer
Chris Gupta
----------------------------------------Simple test may detect breast cancers
Robert Cooke/The Boston Globe The Boston Globe
Thursday, September 23, 200494% of tumors found using urine samples in early U.S. study
BOSTON Researchers have developed a simple urine test that appears to detect breast cancer early and accurately track tumor growth.
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The findings are still preliminary, but if further research supports them, the test could be a major advance in the effort to catch breast cancer before it turns deadly. The scientists, who work for Harvard University at Children's Hospital Boston, are searching for similar markers in urine for other cancers.Earlier this year, a team at the National Cancer Institute reported that other tumors, including prostate cancer, may also be detectable with urine tests. That would be more convenient and inexpensive than the scans, blood tests and biopsies commonly used to screen for and diagnose cancers. Scientists say a screening test that found cancer without needle jabs, intrusive scopes, surgery or radiation would be widely used, improving the odds that tumors would be seen before they spread to other organs, when they are most treatable and least dangerous.
Breast tumors are typically found with a mammogram, a type of X-ray, or when they become large enough to be felt by a woman or her doctor. By then, they may have spread. Further, almost half of women do not get annual mammograms. The result is that 37 percent of breast cancers are diagnosed after they have spread, according to the American Cancer Society.
The society estimates that 215,000 new breast cancer cases will be reported this year in the United States and that about 40,000 women will die of the disease.
Children's Hospital researchers evaluated their new test, which identifies the presence of an enzyme called ADAM 12, in experiments using urine samples from 71 women known to have breast cancer, from early to late stages. The test successfully identified 67, or 94 percent, of the cases. In a control population of 46 women without cancer, there were seven false positive results, or 15 percent. In these seven women, the amounts of the telltale enzyme were very low, the researchers said. The findings have been accepted for publication in the Journal of Biological Chemistry.
"Our data demonstrate for the first time that ADAM 12 can be detected in the urine of breast cancer patients," Marsha Moses, Roopali Roy and their associates wrote in the paper. "Increased urinary levels of this protein correlate with breast cancer progression."
If the results can be repeated in a larger group of patients, the urine test would offer the first noninvasive way to detect breast cancer early, monitor a tumor as it expands, and perhaps keep track of how well treatment is working.
The Harvard research team focused on urine as a place to seek early evidence of cancer, Moses said, because "I wanted something that was noninvasive," a simple, painless and reliable test that accurately warns when tumor growth is getting under way.
Her goal is to offer a test kit that doctors can use routinely in their offices and in hospital laboratories. Eventually, she hoped the test could be done at home. She said that a test could be available within a few years.
"This is important and exciting work," said Dr. Catherine Park, a cancer specialist at the University of California at San Francisco, because it may link an enzyme that plays a role in the growth of a tumor with a detectable measure of how fast the tumor is expanding. She added that it remained to be seen whether the urine test would be accurate enough to provide a "black-and-white answer."
Dr. Sudhir Srivastava, chief of biomarkers research at the National Cancer Institute, said that until more research is done, ADAM 12 must be considered "a putative marker, those that are just at the discovery stage and need to be validated with proper studies."
Noting the small number of patients studied by the researchers, he added, "At this point it looks promising, but it's not ready for prime time."
He said it was surprising that a cancer biomarker, or chemical signal, would be found in urine. The kidneys and liver tend to remove such enzymes and molecules.
Srivastava's program is spending $23 million this year to find cancer biomarkers, including those in urine. National Cancer Institute colleagues reported in February in the Journal of Clinical Oncology evidence that prostate cancer is also detectable with urine tests. The team, working with the Children's Hospital and Harvard scientists, found two biomarkers in urine that seemed to predict the return of cancer in patients who had undergone treatment for prostate cancer.
The urine test for breast cancer seems to identify patients with tumors and also warns of a tumor's severity, distinguishing among patients in varying stages of cancer.
Moses said her experiments showed that when the amount of ADAM 12 in urine spikes sharply, the tumor may be entering a more dangerous growth phase. As a breast tumor gets bigger, and begins sending its deadly "seeds" to lymph nodes and various organs, the enzyme level increases. Moses said the warning's accuracy may improve if ADAM 12 can be combined with other biomarkers in the urine that her lab is studying.
The ADAM 12 enzyme "is a member of a family of enzymes that were only recently discovered," Moses said. "Some of them are associated with cancer, but in general their functions are not well established."
ADAM 12 is suspected of playing a role in remodeling a structure called the extracellular matrix, a cagelike environment in which each cell lives. It helps the cell see and feel its neighbors, helps anchor the cell in place, and facilitates the flow of chemical signals, food and waste into and out of the cell. This structure seems to change constantly to meet the cell's needs, and levels of ADAM 12 may increase, Moses said, when it is changing the extracellular matrix, perhaps to allow the expanding tumor to push through surrounding tissues, or to draw in new blood vessels it needs for growth.
The Boston Globe
posted by Chris Gupta on Monday September 27 2004
updated on Saturday September 24 2005URL of this article:
http://www.newmediaexplorer.org/chris/2004/09/27/simple_test_may_detect_breast_cancers.htm
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