Share The Wealth by Chris Gupta
November 02, 2004

Vitamins Prevent Heart Disease

Here we go again - more stale news dressed up as new. These studies are trying to convince us that nutrients to deal with disease are such a big surprise. Without the building blocks (nutrients) no disease can be cured or mitigated does not require rocket science. But it will take more than rocket science to convince us that we have a deficiency of drugs!!

See comments at: Drano' for arteries works in 6 weeks

Chris Gupta

Two recent scientific publications reported that the risk of heart disease is reduced by half or more in people with high levels of vitamins in their diet and blood. Since a wide variety of vitamins are consumed together, either in multiple supplements or in nutritious, unrefined foods, the population with lowest risk would be expected to have high levels of the whole spectrum of vitamins, minerals, trace elements and antioxidants­although only the vitamins B-6 and folate were specifically measured in these research projects. Strokes have the same underlying cause as coronary heart disease, atherosclerosis (hardening of the arteries), and should therefore benefit equally from this reduced risk.

Tavani A, Pelucchi C, Parpinel M, Negri E, Vecchia CL: Folate and vitamin B(6) intake and risk of acute myocardial infarction in Italy. Eur J Clin Nutr. 2004 Sep;58(9):1266-72.

BACKGROUND: Folate and vitamin B6 intake has been associated with reduced risk of coronary heart disease, but studies are not consistent. OBJECTIVE: The relation between folate and vitamin B6 intake and the risk of acute myocardial infarction (AMI) was assessed in a Mediterranean population. DESIGN: A hospital-based case-control study was conducted in Milan, Italy, between 1995 and 1999. Information was collected by interviewer-administered questionnaires. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) were obtained by multiple logistic regression models. SUBJECTS: Cases were 507 patients with a first episode of nonfatal AMI, and controls were 478 patients admitted to hospital for acute conditions. RESULTS: Compared to patients in the lowest tertile of intake, the ORs for those in the highest tertile were 0.56 (95% CI 0.35-0.88) for folate and 0.34 (95% CI 0.19-0.60) for vitamin B6. The OR was consistently below unity in strata of sex, age, alcohol, methionine, tobacco smoking, coffee, hypertension and family history of AMI; the inverse association was apparently stronger for vitamin B6 in regular alcohol drinkers than in no or occasional drinkers. Compared to subjects with a low intake of both micronutrients, the OR was 0.29 for those with a high intake of both. Compared to subjects reporting no or occasional alcohol drinking and low methionine and folate intake, the OR was 0.28 in regular drinkers with high methionine and high folate intake. The corresponding value for vitamin B6 was 0.25. CONCLUSIONS: A high intake of folates, vitamin B6 and their combination is inversely associated with AMI risk. SPONSORSHIP: Partly supported by "Ministero della Salute" (Contract No. 177, RF 2001). Copyright 2004 Nature Publishing Group

Croft Woodruff

PMID: 15054443 [PubMed - in process]

Voutilainen S, Virtanen JK, Rissanen TH, Alfthan G, Laukkanen J, Nyyssonen K, Mursu J, Valkonen VP, Tuomainen TP, Kaplan GA, Salonen JT: Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2004 Aug;80(2):317-23.

BACKGROUND: Several, but not all, prospective studies have shown that low folate intakes, low circulating folate concentrations, or high plasma total homocysteine (tHcy) concentrations are associated with an increased risk of coronary artery disease (CAD). OBJECTIVE: We examined the relations of both serum folate and serum tHcy concentrations with acute coronary events in middle-aged men from eastern Finland who had no CAD at baseline. DESIGN: In a population-based prospective cohort study, 1027 men aged 46-64 y were examined in 1991-1993 as part of the Kuopio Ischaemic Heart Disease Risk Factor Study. During an average follow-up of 7.7 y (7900 person-years of follow-up), 114 acute coronary events were observed in 61 men who had no previous history of CAD (n = 810). RESULTS: In a Cox model, compared with men whose serum folate concentrations were in the lowest tertile, those whose concentrations were in the highest tertile had a risk factor-adjusted relative risk of acute coronary events of 0.35 (95% CI: 0.17, 0.73; P = 0.005). Serum tHcy concentrations were not significantly associated with the risk of acute coronary events (for the highest tertile compared with the lowest, adjusted relative risk = 1.03; 95% CI: 0.57, 1.87; P = 0.932). CONCLUSIONS: The results of this prospective cohort study do not support the hypothesis that a high circulating tHcy concentration is a risk factor for acute coronary events in a male population free of prior heart disease. However, they do suggest that moderate-to-high serum folate concentrations are associated with a greatly reduced incidence of acute coronary events.

PMID: 15277151 [PubMed - indexed for MEDLINE]


posted by Chris Gupta on Tuesday November 2 2004
updated on Saturday September 24 2005

URL of this article:



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Readers' Comments

Group of doctors created a heart vitamin with vitamins that have been shown to help cholesterol

Posted by: martha on August 21, 2005 01:54 PM


Group of doctors created a heart vitamin with vitamins that have been shown to help cholesterol

Posted by: John on October 3, 2006 06:36 AM


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