Treatment May Fuel Cancer's Spread, Study Finds
CategoriesSeeing the death and carnage here is more validation, as if more was needed....
Chemotherapy is incapable of extending in any appreciable way the lives of patients afflicted with the most common cancers and even the palliative effect of these toxic drugs, which supposedly improve the quality of life, "rests on scientifically shaky ground." That was the conclusion of West German cancer biostatistician Ulrich Abel Ph.D., in the most comprehensive study ever undertaken on cancer chemotherapy. In his 1990 book* Dr. Abel wrote, "There is no evidence for the vast majority of cancers that treatment with these drugs exerts any positive influence on survival or quality of life in patients with advanced disease." The advanced cancers to which Dr. Abel is referring are those malignancies responsible for over 80 percent of the cancer deaths in the Western industrial countries. "Among others, they include nearly all malignant tumors of trachea, bronchus, lung, stomach, colon, rectum, esophagus, breast, bladder, pancreas, ovary, cervix and corpus uteri, head and neck, and liver.. . . Tumors are called advanced if they are recurrent, disseminated, or not radically resectable."
Extracted from : 1953 Fitzgerald Report - Suppressed Cancer Treatments post
* Ulrich Abel, Chemotherapy of Advanced Epithelial Cancer: A Critical Review (Stuttgart, Germany: Hippokrates Verlag GmbH, 1990), available from People Against Cancer, P.O. Box 10, Otho, IA 50569-0010. See also Chemo's Berlin WalI' Crumbles, The Cancer Chronicles, December 1990, pp. 4-5; and "Chemotherapy: A DulI Weapon," Innovation, Spring-Summer 1991 (translation of Der Spiegel article), available from Foundation for the Advancement of Innovative Medicine, P.O. Box 338 Kinderhook, NY 12106-0338.Extracted from: Options by Richard Walters
The fact that any disease including Cancer first and foremost needs a balanced blood chemistry for the body to heal, totally escapes these bozos, instead they continue to waste time and energy with solutions that further impair the delicate body balances... Of course it provides great incentives for perpetual funding and of course all the loot that goes with it.
Chris Gupta
--------------------------For the record,
Andrew Michrowski
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Treatment May Fuel Cancer's Spread, Study Finds
By Maggie Fox, Health and Science EditorThu Apr 5, 10:15 PM ETTreating cancer with surgery, chemotherapy or radiation may sometimes cause tumors to spread and U.S. researchers said on Thursday they may have nailed down one of the causes -- a compound called TGF-beta.
Tests in mice show that using the chemotherapy drug doxorubicin or radiation both raised levels of TGF-beta, which in turn helped breast cancer tumors spread to the lung.
But using an antibody to block TGF-beta stopped the process, Dr. Carlos Arteaga and colleagues at Vanderbilt University in Tennessee reported.
Developing drugs that block TGF-beta might help prevent cancer from recurring, Arteaga's team reports in the May issue of the Journal of Clinical Investigation.
"The repopulation and progression of tumors after anti-cancer therapy is a well-recognized phenomenon," the researchers wrote. "It has been shown to occur following radiotherapy, chemotherapy, and surgery."
Cancer experts have wondered if the so-called primary tumor -- the first and biggest tumor -- might somehow suppress the growth of other tumors, and that removing or destroying the first tumor might allow other, undetectable, tumors to then grow.
TGF-beta, which is involved in both the growth and suppression of tumors, may hold part of the answer, Arteaga's team said.
When mice infected with human breast cancer cells were treated with radiation or doxorubicin, they had higher levels of TGF-beta in their blood. They also had more tiny tumor cells in their blood, and these cells metastasized, or spread, to the lungs.
When the mice were treated with an antibody that suppresses TGF-beta, the spread stopped. And this spreading process did not occur at all in mice bred to lack the TGF-beta protein.
"We wondered then if TGF-beta induced by anti-cancer therapies can serve as a survival signal for tumor cells, thus allowing them to withstand therapy and later recur," Arteaga said in a statement.
His team is now testing TGF-beta levels in the blood of breast cancer patients.
"We'll be looking to see in what proportion of patients the serum and tumor TGF-beta goes up, and whether the increase correlates with the inability of the therapy to eliminate the cancer in the breast," Arteaga said.
Higher levels of TGF-beta after treatment may be a way to predict which patients are likely to have their cancer come back after treatment, Arteaga said.
His team is also testing drugs that interfere with TGF-beta to see if they improve survival.
"It probably isn't just TGF-beta that is having this effect," Arteaga said. Many other compounds, including some immune system signaling chemicals, are also associated with tumor spread and growth.
"TGF-beta may be just the tip of the iceberg," Arteaga said.
posted by Chris Gupta on Monday April 9 2007
URL of this article:
http://www.newmediaexplorer.org/chris/2007/04/09/treatment_may_fuel_cancers_spread_study_finds.htm
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