Share The Wealth by Chris Gupta
January 05, 2004

Coenzyme Q10 Parkinson's disease

Another notch for CQ10... See also: Coenzyme Q10

Could this be a contributing factor with Statin Drugs & Coenzyme Q10 Depletion?

A non drug approach for Parkinson's is also discussed in The Miracle Of Electromedicine post

Also note: "Very high levels of manganese intake have been found to cause Parkinson's disease in manganese miners and other industrial workers. However, case reports of manganese poisoning from oral intake are extremely rare (only one case report exists of toxicity from supplementation; others have been from well water with excess manganese)."

Chris Gupta

Last week, I wrote to you about coenzyme Q10 (coQ10), and how it helps to protect against gum disease. Today I have even more good news about this "miracle" nutrient. Recent research shows that coQ10 may also help slow the progression of Parkinson's disease.

Parkinson's disease (PD) is a neurological disorder that results from a loss of specific motor-control nerve cells in the brain. The result is PD's characteristic muscle tremors, slowed movement, stiffness, and postural disturbances. But since scientists know so little about the disease's origin, treatment and prevention are extremely difficult.

But recently, researchers from medical centers around the country teamed up to identify effective therapies for treating the early signs of PD. They published the results of their study (demonstrating that coQ10 supplementation slows the progression of PD in its early stages) late last year in the Archives of Neurology.

The researchers recruited 80 patients in the early stages of PD to participate in the study. The patients were randomly assigned to one of four groups, receiving a placebo or 300 mg, 600 mg, or 1,200 mg of coQ10 per day. The patients' functional decline was monitored over the next 16 months, using the Unified Parkinson's Disease Rating Scale (UPDRS), which includes a mental score, a motor score, and a rating on activities of daily living.

All three of the coQ10 doses decreased the rate of functional decline in the Parkinson's patients. (The highest dosage produced the greatest effect.) All results were more favorable in the coQ10 groups than in the control group.

The breakthrough results of this study are another notch in coQ10's belt. So it certainly looks like this nutrient has been one of Dr. Wright's recommendation mainstays for good reason. If you want to try it yourself, coQ10 supplements are available in most health food stores and even some pharmacies.

One last thing...

Researchers are currently planning a larger clinical trial that will examine the effects of 1,200 mg/day of coQ10 (and possibly a higher dose as well) in a larger number of Parkinson's patients. Dr. Wright will keep you posted on this amazing anti-oxidant in upcoming issues of Nutrition & Healing (if you're not already a subscriber, visit to learn more about becoming one).

Yours in good health,
Amanda Ross
Managing Editor
Nutrition & Healing

"Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline." Arch Neurol. 2002;59(10):1541-50.

Copyright © 1994 - 2003 by Agora Health, L.L.C.


posted by Chris Gupta on Monday January 5 2004
updated on Saturday September 24 2005

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Readers' Comments

COQ10, because of its mitochondrial functions, is, apparently one notch in the key to most of the Neuromuscular and immune malfunctions as well. Del

Posted by: Del Crow on January 6, 2004 01:14 AM


Interesting reading. My husband was diagnosed with PD approx. 2 yrs ago. Currently in precept study through Yale about 1/2 way through. Tremor present predominant in left side but transferring to right side. Slowness and stiffness. Not on any other meds. Wondering about COQ10 in 1200 mg dose. Will be asking PCP at the next appt. about it. He will need to start something soon - probably one of the agonists. It would be wonderful to not have side effects from drugs just yet. Some of them are scary!!

Keep up the good work!

Posted by: on April 8, 2004 04:08 AM


My father was on Lipitor (statin drug) to lower his cholestoral. His liver produced the enzyme that started attacking his muscles after being on the medication for 4 years. He has come off this medication about a year ago. He is taking prednisone to help with his muscle problems. However he seems to be developing Parkinson Type symptoms. He has tremors in his hands, he has facial twitches, he gets very confused and disorented more and more.He is going to be 71 in September. I am just looking for answers for him. Can a statin drug induce parkinson type symptoms or acutally produce the full blown disease. If so is there anything out there that could help him lead a more normal life?

Posted by: Tammy Robinson on March 7, 2005 02:22 PM


A year and a half ago my mom was said to have pd so I got on the net and read , and read , I found that little study about p d and co q10 , and it took me a month to talk her into taking it , will now I take 150 mg,and she is taking 1200 mg a day,and she is doing good , as for me I stoped taking what I was taking for 5 days and I felt it , my energe went down, so I am back on it GOD help us all,and thank you for your work .

Posted by: Billy on June 10, 2005 07:13 PM


I have the start of Parkinson's disease .I am 72 years old and the Dr. put me last month on Carbidopa 25mg /Levodopa 100mg ..I take a pill 3 times a day..It made me feel good for a few days,but now I am depressed,tired,hav hot flashes and feel really awful.. Have trouble sleeping and am constipated Do I have to be on it quite a long time beforit kicks in..I just don't like the feeling i get with this medecine

Posted by: Joanne on March 14, 2008 03:12 PM


Statin drugs and Co Q10 -
Have read that Statin drugs block and/or deplete Co Q10 in humans, how much Co Q10 should be taken if one is taking a Statin to replace that lost to the drug?


See: Management Of Statin Damage


Posted by: Robert Chamberlin on November 29, 2009 04:53 PM


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