Statin Drugs & Coenzyme Q10 Depletion
Thanks to Ron Law, I have included the patent reference below. This patent was issued in 1989 so this is not new news - one can only wonder of the number of people who died from congestive heart and other issues as a result of this shady tactic...
Further on the theme of, dangerous and useless, Statin Drugs. The following adds another downside as if more are needed - severe nutritional cost of the drug. Merck actually patented (4,933,165) a combination of statin and CQ10 in a pill but never put it on the market, given the marketing shenanigans (patent to prevent others from marketing such a pill) of these scoundrels it is just the thing to do to protect their business with disease.
Now that the cat is out of bag watch them come out with a pill with a good dose of CQ10 and a token statin to salvage the image of statins....
..."Statins could initiate and/or accelerate malignant growth by a) blocking the production of Coenzyme Q10, which has been shown to have anti-cancer effects; b) stimulating the growth of new blood vessels that malignancies require to promote their propagation; c) decreasing the cytotoxicity of natural killer cells; d) blocking the production of squalene, an intermediate cholesterol metabolite with anti-cancer activities in animal studies and currently used as adjunctive therapy in treating cancer; e) reducing the production of DHEA, which has been shown to have anticancer and immune stimulating effects in experimental studies."...
..."Incredibly Merck formula and Patent rights* for CQ10 were sold to the Japanese circa 1958 as this would compete with their blockbuster drug Diuril. Fortunately, the Japanese were able to synthesize large quantities of this nutrient, where is it has been used for over 30 years as an effective treatment for heart disease."...
..."Statin-induced CoQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Furthermore, this drug-induced nutrient deficiency is dose-related and more notable in settings of pre-existing CoQ10 deficiency such as in the elderly and in heart failure."...
Peter H. Langsjoen, M.D., F.A.C.C., Cardiovascular Diseases. Research in Biomedical Aspects of Coenzyme Q10. Tel (903) 595-3778, Fax (903) 595-4962 1107 Doctors Dr., Tyler, Texas 75701,USA.
The depletion of the essential nutrient coenzyme Q10 (CoQ10) by the increasingly popular cholesterol lowering drugs, HMG-CoA reductase inhibitors (statins) has grown from a level of concern to one of alarm. With ever higher statin potencies and dosages, and with a steadily shrinking target LDL cholesterol, the prevalence and severity of CoQ10 deficiency is increasing noticeably to the physicians in the trenches of front line patient care. An estimated 36 million Americans are now candidates for statin drug therapy.
CoQ10 serves as the coenzyme for mitochondrial enzyme complexes I, II and III and is essential for mitochondrial ATP production. CoQ10 is also a clinically relevant fat-soluble antioxidant and is the only fat soluble antioxidant that is known to be synthesized de novo. It is found normally in the diet, predominantly in organ meats and is biosynthesized in all cells with peak capabilities in late teens and early twenties with a gradual age-related decline in blood and tissue CoQ10 levels after the age of 30 years.
Statin-induced CoQ10 depletion has been documented in 15 animal studies in six different animal species and has been shown to correlate with decreased ATP production, increased ischemia reperfusion injury, skeletal muscle injury and increased mortality.
There are 15 published trials on statin-induced CoQ10 depletion in humans. Of these 15 trials, nine were controlled trials, eight of which documented significant CoQ10 depletion. Statin-induced CoQ10 depletion has been shown to be associated with a fall in left ventricular function, an elevation of lactate to pyruvate ratio and an enhancement of LDL cholesterol oxidation. The current data on diastolic dysfunction further confirms the clinical importance of this drug-nutrient interaction.
Statin-induced CoQ10 depletion is well documented in animal and human studies with detrimental cardiac consequences in both animal models and human trials. Furthermore, this drug-induced nutrient deficiency is dose-related and more notable in settings of pre-existing CoQ10 deficiency such as in the elderly and in heart failure. Finally, statin-induced CoQ10 deficiency is completely preventable with supplemental CoQ10 with no adverse impact on the cholesterol lowering or anti-inflammatory properties of the statin drugs.
We are currently in the midst of a congestive heart failure epidemic in the United States, the cause or causes of which are unclear. As physicians, it is our duty to be absolutely certain that we are not inadvertently doing harm to our patients by creating a wide-spread deficiency of a nutrient critically important for normal heart function.
posted by Chris Gupta on Saturday December 13 2003
updated on Saturday September 24 2005
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