Share The Wealth by Chris Gupta
August 19, 2004

B12 Deficiency From Drugs

Further to How To Ingest B12 Orally the following, complements the original post with more data, courtesy of Eddie Vos, and adds serious concerns regarding the impact of drugs on this nutrient. This is, yet again, a clear demonstration on how drugs in addition to their general toxicity continue to exacerbate the very nutrient deficiencies that they pretend to treat under the pretence of a cure no less...

Also note the comment regarding Vitamin C. Its amazing how resilient our bodies are for these Mafioso's to exploit!

Certainly I should prefer the raw oyster route with their superb taste to boot.

Chris Gupta

Subject: RE: B12 and article Canadian Medical Association Journal (
Date: Sun, 15 Aug 2004 22:19:27 -0400
From: "Cory Mermer" =================

You mention that B12 deficiency can be caused by "effects from drugs". One of the biggest culprits, in my humble opinion, are the drugs taken for "upset stomach" or "reflux" or whatever you want to call it. The popular of these recently in the US has been PRILOSEC (Omeprazole) which recently has gone "over-the-counter".

One of the most common and profound adverse effects of omeprazole is that it severely reduces the absorption of cyanocobalamin (vitamin B-12) (Marcuard 94). Increasing this risk further is the fact that a significant percentage of patients taking omeprazole are also being treated for or are at high risk for heart disease, and therefore are almost always instructed to eat a diet low in red meat (or devoid of it completely) and other animal products, which of course are the best source of vitamin B-12.

Also, omeprazole also reduces gastric ascorbic acid (vitamin C) levels (Mowat 99).

In the US, prescription Prilosec has been replaced, I believe, by NEXIUM. I think that NEXIUM works in the same way, and is only a slightly modified version of PRILOSEC.



Marcuard SP, Albernaz L, Khazanie PG. Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B-12). Ann Intern Med 1994; 120: 211-215.

Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999; 116: 813-822.

Marshall E. Deutsch wrote:

Eddie Do you want to tell him that Kilmer McCully told us that oysters are the best source of B12?- M.
Hello Marshall, yes, but not everyone in the group had our pleasure of having oysters with Kilmer and the Ravnkovs in the Union Oyster House in Boston. USDA: oyster = 19 mcg B12/100g [7 medium sized] while beef liver has 60 mcg/100g. Oyster however has 90 mg Zn and ~60 mcg Se -while liver has more of some other B's [300 mcg B9/folate]. 7 oysters will also get you 0.6 g omega-3 [ISSFAL's 'adequate'], beef zero. Both are hard to beat for micronutrients, and flavor!

Maybe, Cory, you can forward this and the attachments to the group. 2 articles on oral B12, the 2nd one [in Blood] is very interesting to the effect that oral may be more effective than injected B12, and that amounts smaller than those used [2 mg/d] are likely to be effective via the process of passive diffusion --and how effectively this therapy lowers homocysteine in these patients. It also illustrated how truly nasty low B12 really is, and how avoidable. It also suggests that these patients ingested little betaine or choline that bypass the Hcy lowering pathway shut by lack of either B9 or B12.

Best, Eddie
-- Wellness: It's the Micro-Nutrients. Stupid! --

Treatment of Vitamin B12Deficiency Anemia: Full paper is here)
Oral Versus Parenteral Therapy
Lenee A Lane and Carlos Rojas-Fernandez

OBJECTIVE: To evaluate the use of oral cyanocobalamin therapy in the treatment of cobalamin (vitamin B12)deficient anemia. DATA SOURCES: Primary and review articles were identified by MEDLINE search (1966May 2000) and through secondary sources. DATA SYNTHESIS: Cobalamin-deficient anemia is among the most common diagnoses in older populations. Cobalamin-deficient anemia may be diagnosed as pernicious anemia, resulting from the lack of intrinsic factor required for cobalamin absorption or as protein malabsorption from the inability to displace cobalamin from protein food sources. Several studies provide evidence that daily oral cyanocobalamin as opposed to monthly parenteral formulations may adequately treat both types of cobalamin-deficient anemias.

CONCLUSIONS: Daily oral cyanocobalamin at doses of 10002000 µg can be used for treatment in most cobalamin-deficient patients who can tolerate oral supplementation. There are inadequate data at the present time to support the use of oral cyanocobalamin replacement in patients with severe neurologic involvement.

KEY WORDS: cobalamin, cobalamin deficiency, pernicious anemia, vitamin B12.
Ann Pharmacother 2002;36:1268-72.
Author information provided at the end of the text.

Treatment of Cobalamin Deficiency With Oral Cobalamin (Full paper is here)
By Antoinette M. Kuzminski, Eric J. Del Giacco, Robert H. Allen, Sally P. Stabler, and John Lindenbaum

Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or 2 mg orally on a daily basis for 120 days. Therapeutic effectiveness was evaluated by measuring hematologic and neurologic improvement and changes in serum levels of cobalamin (normal, 200 to 900 pg/mL) methylmalonic acid (normal, 73 to 271 nmol/L), and homocysteine (normal, 5.1 to 13.9 mmol/L). Five patients were subsequently found to have folate deficiency, which left 18 evaluable patients in the oral group and 15 in the parenteral group. Correction of hematologic and neurologic abnormalities was prompt and indistinguishable between the 2 groups. The mean pretreatment values for serum cobalamin, methylmalonic acid, and homocysteine were, respectively, 93 pg/mL, 3,850 nmol/L, and 37.2 mmol/L in the oral group and 95 pg/mL, 3,630 nmol/L, and 40.0 mmol/L in the parenteral therapy group. After 4 months of therapy, the respective mean values were 1,005 pg/mL, 169 nmol/L, and 10.6 mmol/L in the oral group and 325 pg/mL, 265 nmol/L, and 12.2 mmol/L in the parenteral group. The higher serum cobalamin and lower serum methylmalonic acid levels at 4 months posttreatment in the oral group versus the parenteral group were significant, with PF .0005 and PF.05, respectively. In cobalamin deficiency, 2mg of cyanocobalamin administered orally on a daily basis was as effective as 1 mg administered intramuscularly on a monthly basis and may be superior.

© 1998 by The American Society of Hematology.


posted by Chris Gupta on Thursday August 19 2004
updated on Saturday September 24 2005

URL of this article:



Related Articles

Artificial Water Fluoridation: Off To A Poor Start / Fluoride Injures The Newborn
Please watch this short 5 minute video: Little Things Matter: The Impact of Toxins on the Developing Brain Toxins such as Arsenic, Lead, Mercury, Aluminum and other known and unknown chemicals, that are often above the legal limits, are deliberately added to our water to manage the disposal of toxic industrial waste chemicals under the pretense of "safe and effective" for water fluoridation mantra.Knowing and acting on the above should... [read more]
December 30, 2014 - Chris Gupta

Drinking Water Fluoridation is Genotoxic & Teratogenic
This paper by Prof. Joe Cummins is a very important 5 minute delegation made to London Ontario Canada "Civic Works Committee" public participation meeting on January 25, 2012 on fluoride*. While a bit technical it is short and easy to grasp. A must read as it goes to the heart of the matter regarding the well established toxicity of fluoride which is well in all scientific circles even before water... [read more]
February 06, 2012 - Chris Gupta

Democracy At Work? - PPM On Fluoride
Here is a commentary on the recent (Jan, 25th, 2011) Public Participation Meeting (PPM) on Fluoride in the City of London, Ontario. The meeting started with a strong pro fluoride stance form the City engineer. His lack of knowledge on chemistry of the toxic wastes used to fluoridate water could embarrass even a high school student never mind his own profession. He blatantly violated his "duty to public welfare" as... [read more]
January 29, 2012 - Chris Gupta



Readers' Comments

Hi, my name is Brenda and I am currenty taking tegretal and I also heard that this medicine could cause Vitimin Def. when taken long term. I never seem to have enough energy. Would extra B12 be okay for me? I hate that I have to take this med.but I do and I think med. long term can cause problems. I just want to do the best thing when taking Vitamins. Thank-you for your time.

Posted by: Paul E. Tooley, Sr. on July 11, 2005 10:24 PM


Hi, my name is Brenda and I am currenty taking tegretal and I also heard that this medicine could cause Vitimin Def. when taken long term. I never seem to have enough energy. Would extra B12 be okay for me? I hate that I have to take this med.but I do and I think med. long term can cause problems. I just want to do the best thing when taking Vitamins. Thank-you for your time.

Posted by: Gerald Sutliff on November 23, 2005 03:04 PM


Hi, my name is Brenda and I am currenty taking tegretal and I also heard that this medicine could cause Vitimin Def. when taken long term. I never seem to have enough energy. Would extra B12 be okay for me? I hate that I have to take this med.but I do and I think med. long term can cause problems. I just want to do the best thing when taking Vitamins. Thank-you for your time.

Posted by: Brenda Lee on October 24, 2006 11:08 AM


Security code:

Please enter the security code displayed on the above grid

Due to our anti-spamming policy the comments you are posting will show up online within few hours from the posting time.




A Person Is Only As Valuable As She Can Be Of Help To Others


Creative Commons License
This work is licensed under a Creative Commons License.

These articles are brought to you strictly for educational and informational purposes.
Be sure to consult your health practitioner of choice prior to any specific use of any of the non drug device or food based medicinal products referenced herein.



Enter your Email

Preview | Powered by FeedBlitz



Most Popular Articles

Bad News About Statin Drugs

Cod Liver Oil - Number One Superfood

Statin Drugs & Memory Loss

Cold remedies that really work.- update




Recent articles
Drinking Water Fluoridation is Genotoxic & Teratogenic

Democracy At Work? - PPM On Fluoride

"Evidence Be Damned...Patient Outcome Is Irrelevant" - From Helke

Why Remove Fluoride From Phosphate Rock To Make Fertilizer

FOFI Codex Meeting Report On Labelling May 9 - 13, 2011

Misconduct Of Health Canada Bureaucrats

Archive of all articles on this site



Most recent comments

Cold remedies that really work.- update

Why Doctors Don't Recommend More The Use Of Coq10?

Re: Dispelling the Night-Time Frequent Urination

Health via Meditation/Stress Reduction

Build a Low cost & simple Magnetic Pulser



Candida International

What Does MHRA Stand For??

Bono and Bush Party without Koch: AIDS Industry Makes a Mockery of Medical Science

Profit as Usual and to Hell with the Risks: Media Urge that Young Girls Receive Mandatory Cervical Cancer Vaccine


Health Supreme

Multiple sclerosis is Lyme disease: Anatomy of a cover-up

Chromotherapy in Cancer

Inclined Bed Therapy: Tilt your bed for healthful sleep


Evolving Collective Intelligence

Let Us Please Frame Collective Intelligence As Big As It Is

Reflections on the evolution of choice and collective intelligence

Whole System Learning and Evolution -- and the New Journalism

Gathering storms of unwanted change

Protect Sources or Not? - More Complex than It Seems



Islanda, quando il popolo sconfigge l'economia globale.

Il Giorno Fuori dal Tempo, Il significato energetico del 25 luglio

Rinaldo Lampis: L'uso Cosciente delle Energie

Attivazione nei Colli Euganei (PD) della Piramide di Luce

Contatti con gli Abitanti Invisibili della Natura


Diary of a Knowledge Broker

Giving It Away, Making Money

Greenhouses That Change the World

Cycles of Communication and Collaboration

What Is an "Integrated Solution"?

Thoughts about Value-Add


Best sellers from