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September 16, 2005

Corrupted Research: Most Scientific Findings Are False

Published Research is majorly false. That is the upshot of a recent Greek study which examined the outcomes of scientific studies against subsequent research which proved them unreliable. It seems that most studies "find" whatever outcome the funders desire.

With most funding for health related research coming from pharmaceutical companies, it is no wonder that there should be a certain bias. Contradictory outcomes of studies are common. Many of the false studies are trumpeted up in the press as if previous research they contradict did not exist, even if study quality is extremely dubious. Both scientific research and the media are involved in this game.

See article in Public Library of Science.

Michael Meacher, a former UK government minister, expanded on the issue of corrupt science in his keynote address to the Green Network Conference, Science, Medicine and the Law, held at the Royal Institute of British Architecture in London in February this year.

Which Science or Scientists Can You Trust?

(found on Omega News)

Michael Meacher told a public conference on Science, Medicine and the Law in the strongest terms that we need independent science and scientists who take the precautionary principle seriously and sweeping changes are needed in science funding and scientific advice to the government that ensures the protection of independent science

Which scientists?

Nobody disagrees that debate over whether we should go ahead with new technologies should be conducted on the basis of science, but which science? Independent science or industrial science? Let me test out a few examples on you.

Fifteen years ago a lorry driver accidentally tipped 20 tonnes of aluminium sulphate into the public drinking supply in north Cornwall – nearby residents and local doctors are convinced they were poisoned; but two Government enquiries found no evidence. Whom do you believe?

There are childhood leukaemia clusters in villages down the Cumbrian coast – local residents and independent scientists think it is the consequence of chronic exposure to low-level radiation from nearby Sellafield; but the Department of Industry (DTI) and British Nuclear Fuels (BNFL) think it is nothing to do with local nuclear power stations – their best explanation is that it is caused by high levels of inward and outward migration. Whom do you believe?

Mark Purdey, a Somerset farmer turned epidemiologist, has produced detailed evidence to show that BSE was caused by farmers spreading Phosmetz, an organohosphate (OP), over the backs of cattle as a prophylaxis, but the Government's MRC Toxicology Unit - funded by the pharmaceutical company Zeneca - apparently refuted this theory. Which company held all rights over the production of Phosmetz? Zeneca. Whom do you believe?

Gulf War Syndrome has been a persistent disabling, and sometimes lethal, condition since the first war in Kuwait in 1991. Both UK and US soldiers and their independent scientific advisers are convinced that the soldiers were poisoned by the OP insecticides that they were liberally sprayed with. But the MOD and chemical companies insist there is no evidence for this. Whom do you believe?

Well, if you have any doubts, look at what has actually happened in the past when Government, in the teeth of overwhelming evidence, have often finally been forced to back track from entrenched positions that they always said were supported scientifically.

Science can quite often get things wrong.

Which science?

Government biologists initially refused to accept that power stations in Britain or Germany could kill fish or trees hundreds of miles away in Scandinavia ; later the idea of acidification caused by SO2 was universally accepted.

Government scientists originally did not agree that chlorofluorocarbons (CFCs) were destroying the ozone layer; but during the 1987 negotiations on the Montreal Protocol the industry – ICI and Du Pont – abruptly changed sides, and ministers and scientists soon fell into line alongside them.

The Lawther working party of Government scientists roundly rejected any idea that health-damaging high levels of lead in the blood came overwhelmingly from vehicle exhausts, only to find that after lead-free petrol was introduced, blood-lead levels fell 70%.

The Southwood committee of BSE scientists insisted in 1990 that scrapie in cattle could not cross the species barrier, only to find by 1996 that it did just that. And there are many more examples.

Scientific uncertainty and the precautionary principle

The only way to deal with these problems is by applying the precautionary principle. Perhaps the classic formulation of the precautionary principle was at the Rio Summit in 1992 principle 15: “in order to protect the environment, the precautionary approach shall be widely applied by states according to their capabilities. Where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation.”

That principle survived renegotiation attempts during the Johannesburg Summit in September 2002, and was reaffirmed in the Plan of Implementation that resulted from the Summit .

Why has this not been adopted by scientists and policy-makers? There can be only one reason: cynicism of not disturbing powerful political and economic interests.

It is highly disturbing to realise how long it takes for poisonous chemicals to be banned after scientific evidence emerged that they were harmful.

* Benzene was demonstrated as powerful bone marrow poison in 1897

* Acute respiratory effects of asbestos was identified 1898

* The ability of PCB to induce chloracne was documented in 1898

But it was not until 1960-70s that significant progress was made in restricting damages caused by these agents.

Independent scientists vilified

Efforts were made to discredit independent critics, as in the case of Richard Lacey and Mark Purdey in BSE, & Arpad Pusztai in GM food, and too many other examples.

Data and reports have been regularly suppressed or publishers intimidated, as in the Great Lakes chemical case.

The Southwood Committee on BSE believed a ban on the use of all cattle brains in human food chain might be justified, but considered that politically unfeasible.

There was also incompetence: the Department of Health was not informed by MAFF (the then Ministry of Agriculture, Fisheries and Food, now disbanded) about the emergence of new disease (BSE) until 17 months after MAFF was first alerted.

Pervasive mistrust of science and scientists

No wonder that there is a pervasive mistrust of science and scientists. But the roots for this go deep.

First, the Rothschild revolution under Thatcher made the funding of science much more subservient to business interests. Over the past two decades, getting finance for scientific inquiry inimical to the commercial and political establishments has become increasingly difficult. The science is owned by a tiny number of very large companies and they only commission research which they believe will further their own commercial interests. And when that turns out not to be the case, as when research turns up results which may be embarrassing to the company, they are most often dubbed “commercially confidential” and never published.

In addition, companies have learned that small investments in endowing chairs, sponsoring research programmes or hiring professors for out-of-hours projects can produce disproportionate payoffs in generating reports, articles, reviews and books, which may not be in the public interest, but certainly benefit corporate bottom lines. The effects of corporate generosity - donating millions for this research laboratory or that scientific programme – can be subtly corrosive. Other universities regard the donor as a pote ntial source of funds and try to ensure nothing is said which might jeopardise big new cash possibilities. And academics raising embarrassing questions (as they should) - such as who is paying for the lab; how independent is the peer review; who profits from the research; is the university's integrity compromised? – would soon learn that keeping their heads down is the best way not to risk their career, let alone future research funding. The message is clear: making money is good, and dissent is stifled. Commerce and the truth don't readily mix.

A second reason why there is such pervasive mistrust of science and scientists is that the scientists staffing the official advisory committees and Government regulatory bodies in a significant number of cases have financial links with the industry they are supposed to be independently advising on and regulating. A recent study found that of the five scientific committees advising ministers on food and safety, 40% of committee members had links with the biotechnology industry, and at least 20% were linked to one of the Big Three – Monsanto, AstraZeneca, or Novartis. Nor is that an accident. The civil servants who select scientists for those bodies tend to look for a preponderant part of the membership, and particularly the chairperson, to be ‘sound', i.e., can be safely relied on not to cause embarrassment to the Government or industry if difficulties arise.

Third, the culture of spin and intimidation is far more pervasive than should ever be allowed. The shocking sacking and vilification of Dr Arpad Pusztai, when he produced GM research results inconvenient to the Government, bio-tech industry and the Americans, was no doubt, deliberately intended as a warning to others if they stepped out of line. And the threats and insinuations made clear to the only two independent scientists on the UK Government's GM Science Panel, Dr Carlo Leifert and Andrew Sterling, demonstrates all too clearly how viciously the Establishment will fight to safeguard its own interests.

And on spin, how many times have we heard the false argument that is still regularly deployed by ACRE , the Government's main GM advisory committee, when it announces that, “there is no evidence that this GM product is any greater risk to human health than its non-GM counterpart”. In fact they have not sought such evidence directly, merely relied on the biotech companies telling them that their GM product was ‘substantially equivalent' to its alleged non-GM analogue.

Fourth, science is not, and never has been, a value-free search for the truth. It is a social construct influenced by a variety of rules, peer group pressures, and personal and cultural expectations. It is developed, like all human thought, from preconceived built-in judgements, assumptions and dogmas, the more powerful because they are often unconsciously held.

So what is to be done?

What all this means is that science can only be fully trusted if it is pursued with the most rigorous procedures that guarantee total independence and freedom from commercial and political bias. That is far too often not the case today. The implications for policy are clear.

One, if the Government truly wants independent research, it has to be prepared to pay for it, not lay down, as it has, that 25% of finance for publicly funded research should come from private sources, thus forcing the universities into the hands of corporate sponsors.

Two, the Government should also require that no member of its advisory committee or regulatory bodies should have any current or recently past financial or commercial link with the industry concerned.

Three, contributors to scientific journals should be required to make full disclosure of current and prior funding sources, so that any conflicts of interest can be exposed and taken into account.

Four, we need above all a Government with the political gumption to stand up to the United States and those demanding calls from the White House, to stand up to the biotech companies, and to stand up to big business, and make clear that there will be no succumbing to dominant political /economic interests, e.g. no growing of GM crops in this country until proper, systematic, independent, peer-reviewed research, which is totally absent at present, has been carried through and made public which demonstrates beyond any reasonable doubt whether GM foods are safe or not.

We should never forget the words of Winston Churchill, who said “Science should be on tap, not on top”.

This is an edited version of Michael Meacher's keynote address to the Green Network Conference, Science, Medicine and the Law, 31 January to 2 February 2005 , Royal Institute of British Architecture, London , UK , which will be published in issue 26 of Science in Society http://www.i-sis.org.uk


See also:


Most Published Medical Research Is False - According to an Article in a Medical Journal


Reporting © By Peter Barry Chowka

(September 1, 2005) As this article is being written, Hurricane Katrina's assault on the city of New Orleans and several states on the Gulf of Mexico and the unprecedented and largely indescribable, horrendous aftermath are reminiscent of the September 11, 2001 terrorist attacks on the U.S. - and are eclipsing almost everything else on the current events landscape.

Nonetheless, in the midst of this compelling, deeply traumatic national news, several recent developments relating to alternative medicine should not be overlooked.

The August issue of PLoS Medicine (Public Library of Science), the contents of which are open access and freely available online, includes an article by John Ioannidis, Ph.D. titled "Why Most Published Research Findings Are False."

As the New Scientist news service reported on August 30, "Most published scientific research papers are wrong, according to a [Ioannidis'] analysis. Assuming that the new paper is itself correct, problems with experimental and statistical methods mean that there is less than a 50% chance that the results of any randomly chosen scientific paper are true."

In the summary of his article, Ioannidis writes: "There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field . . . Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias."

An accompanying editorial published online on August 30, by the PLoS editors, is titled "Minimizing Mistakes and Embracing Uncertainty."

The analysis and the editorial represent a provocative and refreshing break with the group think that characterizes much of modern medicine.

Ioannidis' analysis and the PLoS editorial are additionally interesting to consider, especially in light of the plethora of recent studies that dismiss out of hand various aspects of alternative medicine.

A particularly high profile example was published by the New England Journal of Medicine (NEJM) on July 28, 2005, on the alleged lack of effectiveness of the herb echinacea on colds. As reported here earlier, this study seems highly flawed.

Studies, papers, reports, and clinical case histories in a similar vein (if not quite commanding as high a profile or as much media and public attention) are published in the medical and scientific literature on virtually a daily basis. They are serving to establish a quasi-scientific basis - a significant official-sounding paper trail - for the serious dismissal of alternative medicine, while the questionable area of complementary alternative medicine (CAM) or integrative medicine is allowed and encouraged by the powers that be to advance to the highest levels of acceptance.

A clinical case history, "Life-Threatening Interaction Between Complementary Medicines: Cyanide Toxicity Following Ingestion of Amygdalin and Vitamin C" by four Australian researchers, appears in the September 2005 issue of The Annals of Pharmacotherapy and was published online on July 12. The report's objective is "To describe a case of severe accidental cyanide poisoning following a single ingestion of amygdalin with therapeutic intent." The authors identify the role of 4.8 grams of vitamin C ingested by the patient as the culprit in her alleged cyanide toxicity.

As much discussion in the four page article is given to a perjorative, selective, and at times inaccurate review of the history of amygdalin (Laetrile), a highly controversial subject, as to the merits of the case at hand. Among the article's errors: The authors cite the experience of leading American actor Steve McQueen in 1980 with alternative cancer therapy (Laetrile is the only component of McQueen's comprehensive therapy that they mention) as "perhaps more telling. He travelled to Mexico to undergo treatment with laetrile at a clinic in 1980 and died within a few weeks of commencing treatment." The source for this conclusion is an article, "The Rise and Fall of Laetrile," at quackwatch.com.

In fact, McQueen's therapy consisted primarily of the comprehensive metabolic approach of William Donald Kelley, D.D.S., and the actor died six months or more (not a "few weeks") after first traveling to Mexico to begin alternative cancer treatments. He was diagnosed with mesothelioma in Los Angeles at a leading conventional institution during the winter of 1979-1980 and his prognosis at that time was terminal months before he set foot in Mexico.

While citing a negative study of Laetrile in the New England Journal of Medicine by Charles Moertel, M.D. et al in 1982, the authors neglect to mention positive studies of Laetrile including a retrospective review of Laetrile case histories, also published in NEJM on September 7, 1978, which found, of 68 patients treated with Laetrile, "six Laetrile courses to have produced a response (two complete and four partial)."

In a highly politicized but uniquely thorough and largely positive study published in 1978 in the Journal of Surgical Oncology (also ignored by the Annals of Pharmacotherapy article authors), veteran cancer researcher Kanematsu Sugiura, D.Sc., of Sloan-Kettering in New York, found that Laetrile stopped the spread of cancer in mice and was, he told me in an interview on February 25, 1978, an effective palliative chemotherapeutic agent.

Another negative review of an alternative cancer therapy, based on a single case, was published in the September 2005 issue of the Journal of the American Academy of Dermatology: "Self-treatment of a basal cell carcinoma with 'black and yellow salve.'" The authors are several physicians and others associated with the U.S. military. A full text copy of the report has not yet been obtained. The abstract, however, describes the study: "Patients may seek 'alternative' or 'non-traditional' therapies for dermatologic problems, frequently in search of a miraculous cure. However, many of these medicaments contain unknown compounds with questionable benefit and a potential for significant harm. We describe a patient who developed a large ulceration on her nose after applying 'black and yellow salves' obtained from Mexico in an attempt to self-treat a basal cell carcinoma." It is possible, if not probable, that the salve in question is part of the Hoxsey herbal cancer therapy.

Typical of an avalanche of other studies that amount to vague warnings against alt med (herbal and nutritional supplements in particular) is "Herb-drug interactions between ginseng and prescription medications" published in Geriatrics in August 2005. This article cautions physicians against potential effects of herbs and pharmaceutical drugs and advises them "to ask their patients about any herbal and dietary supplements that they might be taking." It is not clear what the clinicians are expected to do when they presumably learn more about their patients' use of supplements; presumably, caution them against such usage.

Along an almost identical line, the August 2005 issue of Pediatric Emergency Care published an article "Differences in Herbal and Dietary Supplement Use in the Hispanic and Non-Hispanic Pediatric Populations." The objective: "To describe the cultural differences in the use of herbal and dietary supplements in the Hispanic and non-Hispanic-Caucasian outpatient pediatric populations." The conclusions: "There is significant use of complementary and alternative medicine in the pediatric population, and herbal and dietary supplement use varies between Hispanic and Caucasian children. In addition, this dietary supplement use is often not discussed with health care providers. These factors should be taken into consideration by all health care providers."

 


posted by Sepp Hasslberger on Friday September 16 2005
updated on Friday November 19 2010

URL of this article:
http://www.communicationagents.com/sepp/2005/09/16/corrupted_research_most_scientific_findings_are_false.htm

 


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Readers' Comments


Here is a pertinent comment by Vera Hassner Sharav of the
ALLIANCE FOR HUMAN RESEARCH PROTECTION (AHRP)
Promoting Openness, Full Disclosure, and Accountability
www.ahrp.org

An article published in PLoS Medical (an Open Access Peer Reviewed Medical Journal) by an epidemiologist who holds academic positions on both sides of the Atlantic -- at the University of Ioannina (Greece) and Tufts University (Massachusetts) -- knocks the socks off much of what passes the peer review process of medical journals. 

Dr. John Ioannidis examines, what he says are the key factors that have resulted in mostly false, published medical research reports:

"There is increasing concern that in modern research, false findings may be the majority or even the vast majority of published research claims."

Dr. Ioannidis notes that the probability that a research finding is indeed true depends on "the prior probability of it being true (before doing the study), the statistical power of the study, and the level of statistical significance."  He notes the high rate of nonreplication -- a sure sign of the findings being false.

"What is less well appreciated is that bias and the extent of repeated independent testing by different teams of investigators around the globe may further distort this picture and may lead to even smaller probabilities of the research findings being indeed true….Several independent teams may be addressing the same sets of research questions. As research efforts are globalized, it is practically the rule that several research teams, often dozens of them, may probe the same or similar questions. Unfortunately, in some areas, the prevailing mentality until now has been to focus on isolated discoveries by single teams and interpret research experiments in isolation. An increasing number of questions have at least one study claiming a research finding, and this receives unilateral attention. The probability that at least one study, among several done on the same question, claims a statistically significant research finding is easy to estimate."

Dr. Ioannidis defines bias as "the combination of various design, data, analysis, and presentation factors that tend to produce research findings when they should not be produced.

Let u be the proportion of probed analyses that would not have been “research findings,?? but nevertheless end up presented and reported as such, because of bias."

He differentiates bias from chance variability "that causes some findings to be false by chance even though the study design, data, analysis, and presentation are perfect."

"Bias can entail manipulation in the analysis or reporting of findings. Selective or distorted reporting is a typical form of such bias." 

Dr. Ioannidis' observation that "claimed research findings may often be simply accurate measures of the prevailing bias," is especially applicable to psychiatry.


The focus of a forthcoming presentation by Dr. David Healy, "Psychopharmacology in Turmoil: A Scientific or Ethical Crisis?" is bias, faulty data analysis, and manipulated clinical trial finding reports as manifested in the psychiatric literature. In his lecture, at Columbia University Medical Center (October 20), Dr. Healy will demonstrate how current clinical practice guidelines that purport to be "evidence-based" are not not based on scientifically valid evidence at all. 

For those who are unaware of Dr. Healy's contribution to the credibility crisis in psychiatry: his analysis of previously undisclosed company data from SSRI drug trials contradicted the published reports about these trials. His findings of a drug-induced suicide risk, challenged the mindset and prescribing practices of the psychiatric establishment in the UK, Canada, Australia, and the US. By bringing the undisclosed hazards to public notice, the debate about the efficacy and safety of SSRIs -- and the validity of the process by which they were tested--reached a crescendo.

Families whose children became suicidal after being prescribed an SSRI -- some becoming casualties of drug-induced suicide -- came to Washington from coast to coast to testify before two FDA advisory committee hearings (in February and September, 2004). Their compelling testimonies coupled with independent analyses replicating Dr. Healy's, resulted in mandatory Black Box warnings about the drugs posing a twofold risk of suicidal behavior for adolescents.

For those who are unable to attend -- as well as those who want to familiarize themselves with the issues -- as they stood in 2003 -- a video of Dr. Healy's Grand Rounds presentation at UCLA, Neuropsychiatric Institute, "How Pharmaceutical Companies Mold our Perceptions of Mental Illness"  (October 28, 2003)

is on view at:  http://www.mentalhealth.ucla.edu/opce/gr0304.html

"Psychopharmacology in Turmoil: A Scientific or Ethical Crisis?"
Date: Thursday, October 20
Time: 12:30 - 2:00
Location: Columbia Presbyterian Hospital -- 622 West 168th Street
10th floor - Irving Conference Room

Directions from Penn Station: take the #1 train (red line) uptown or the A train (blue line) uptown to 168th street.
At 168 Street station (#1 train) take the elevator up to 168th and Broadway
A train: just go up the stairs to 168th and Broadway
From trains: walk west on 168th street 1/2 block to circular driveway: Presbyterian Hospital 622 west 168th street get a pass from the guard. take elevator behind the guard desk to the 10th floor go through the doors to the Irving Conference Room.

After the lecture there will be aboout 40 minutes for Q & A


Contact: Vera Hassner Sharav
212-595-8974
veracare@ahrp.org

Posted by: Sepp on October 9, 2005 11:52 AM

 


I want to thank you for bringing out the truth about the claims made about psychiatric drugs and how the public is not being told the truth in regards to research studies and other things of importance.

I have been a victim of the practices of the psychiatry and pharmaceutical industries and it is inhumane what these people are doing. My involvement with them started because of a bad experience I had many years ago and they used and took advantage of those within my family to have permission to use their brand of science on me. Some of them probably know that they need all the support they can get to protect themselves knowing that what they are doing is wrong and only serves their own selfish interests. I am amazed at how many supporters they have that would not want to be in the same situation as others like myself have.

And then, to not be allowed to have the right to refuse their type of "therapy" goes too far!! It does little or nothing to advance an individual so they can progress and use the God-given talents they have to make a difference in the lives of others. For any society to expect an individual to live up to their unfair demands and perfectionist ideas is terrible!

Not one of us are the same in design and we all have our own strengths and weaknesses. At least some of the courts of our land are biased also. You can have a lawyer to defend you, which sometimes helps, but have you noticed that the judge makes the final decision? Do you want to talk about the Terry Schiavo case? Her parents were willing to take care of her and she was denied the right to live by a judge! I just hope and pray that we are rescued and delivered from this injustice that we have been subjected to much too long!

Thank you once again for your site. I am going to share this with a human rights group that is trying to help those who have been labeled as "mentally ill." I wish you success and blessings in your quest to inform others about what is actually going on. I have noticed more and more reports coming out against natural alternatives and even vitamins.

God bless you!!

Posted by: Sylvia on November 17, 2008 04:20 AM

 















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