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January 28, 2006

Chemicals Better Than Nature? - Perhaps Not

A recent report from the UK-based group Sense About Science titled Making Sense of Chemical Stories challenges the concept that natural is better for our health than chemical. Chemical substances are often safer than natural ones and are being unfairly blamed for cancer and other illnesses, the report says. Those suffering from Multiple Chemical Sensitivity/Chronic Fatigue Syndrom (MCS/CFS) would disagree. Sometimes one heavy exposure to a toxic substance is enough to sensitize a person to a class of chemicals and turn the life of the victim into pure hell.

The flat-out denial of the existence of illness as a consequence of damage from chemicals can ruin people's lives and worse, it will work to deny them real help. The power politics that have led certain medical authorities to recommend psychiatric treatment, rather than prevention and detoxification to help victims of chemical poisoning, is outlined in Martin Walker's book "Skewed". More information can be found on Diana Buckland's Global Recognition Campaign for Sufferers of Multiple Chemical Sensitivity, on the Washington State Multiple Chemical Sensitivity Network and on Gordon McHendry's Satori-5 site reporting from Scotland.

Nutraingredients.com announced the new report with this article. The full text is available in PDF format from the Sense About Science website.

Neil Levin, a nutritionist from the US, says that Sense About Science is biased and unconvincing in its arguments. Levin's piece was published by Nutraingredients and the editors are inviting comments from other readers.

Sense About Science, says Martin Walker in his new book "Brave New World of Zero Risk", is a "highly-politicised organisation, which campaigns in support of science, is funded by the Association of the British Pharmaceutical Industry (ABPI), a number of individual pharmaceutical companies, and other corporate concerns."

Martin Walker's free e-book, which is available from Slingshot pubs outlines the connections between this "scientific" group and the movers and shakers in industry - especially the pharmaceutical branch - as well as government. Walker's conclusion: "There can be no doubt that Sense About Science, a lobby organisation funded entirely by corporate interests and boasting on its board a number of people who have access to the Prime Minister's Policy Unit, is primarily a crisis management PR entity."

When Tracey Brown, the director of Sense About Science tells us of the "chemical realities of the world" saying "that everything is made of chemicals, that synthetic chemicals are often much safer for human health than so-called ‘natural’ ones, and that unfounded anxiety about chemicals is encouraging people to buy into ideas and ‘remedies’ that make little scientific or medical sense", we may well be justified thinking that the views expressed in her report could have been influenced by the industries that founded and continue to finance her group. My money is certainly on it!

Here is a copy of Neil Levin's reply as published on Nutraingredients.com:

- - -

Who's trying to fool Mother Nature?

by Neil E. Levin, CCN, DANLA

The scientists at Sense About Science (SAS) have issued a document, with much publicity, that is a thinly veiled attempt to assure us not to be afraid of synthetic chemicals (Making sense of chemical stories). I have read it and am afraid that they have issued a most unscientific document, containing few references and more fittingly called a chemical industry public relations piece. But it may be convincing to people who lack a working knowledge of chemistry.

Their assertion that “synthetic chemicals are often much safer for human health than so-called ‘natural' ones” is backed up only by the most simplistic arguments, without giving references from published scientific literature. The first obvious problem is that the processes of synthesizing chemicals usually do not result in 100% pure substances. There are often impurities that do not exist in similar, natural chemicals in food or in the unpolluted, natural environment that our human bodies have evolved to deal with for hundreds of generations. So we are frequently dealing with not just a synthetic chemical, but the impurities that are wed to it. And not just one ‘foreign molecule', as the scientific community used to call such chemicals, but unstudied mixtures of tens of thousands of such foreign chemicals that are now present in our food and the environment.

Yet the SAS report astonishingly claims that lab-made chemicals can eliminate “some of the impurities and toxic effects that are present in natural sources”, as if the food matrix that natural chemicals are found in are considered a problem. Certainly man-made chemicals are the main source of persistent toxins in the environment. The report also ignores the hormone disrupting effects of many classes of man-made chemicals. The US Environmental Protection Agency finds ‘compelling evidence' of these effects:

“In recent years, some scientists have proposed that certain chemicals might be disrupting the endocrine system of humans and wildlife. A variety of chemicals have been found to disrupt the endocrine systems of animals in laboratory studies, and compelling evidence shows that endocrine systems of certain fish and wildlife have been affected by chemical contaminants, resulting in developmental and reproductive problems. Based on this and other evidence, Congress passed the Food Quality Protection Act in 1996, requiring that EPA initiate EDSP to screen pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife.”

The EPA issues a Toxic Release Inventory (TRI) report of hundreds of chemicals known to be toxic, stating that: “The chemicals that are reported under TRI can have significant adverse effects on human health and the environment. They include carcinogens -- chemicals that cause cancer, such as dichloroethane and benzene – and mutagens – chemicals that can cause changes in human cells, such as ethylene di-bromide as well as chemicals that cause reproductive and developmental effects.”

It is not accurate for the SAS report to state that: “Although synthetic products may contain substances known to be harmful in large quantities, the amounts contained in consumer products are so negligible that they would not even have an effect when all products are considered.”

Who is even investigating these millions of potential multiple chemical interactions? Adding minute doses of various chemicals together may not reveal the true body burden to an individual. If chemicals are difficult to detoxify and a person has a diminished capacity to do so due to inflammation, illness or nutrient deficiencies, the cumulative toxic effects could be dramatic.

The government of the UK has acknowledged the problem inherent in large amounts of chemicals in the environment. The Department for Environment, Food and Rural Affairs has reported:

“There are, however, concerns about the risks to the environment and to human health which might be present from some of the chemicals we use, as was set out in the Government's Chemicals Strategy "Sustainable production and use of chemicals":

"In recent years there has been growing concern about the possible effects of man-made chemicals on human health through environmental exposure. Some confidence can be gained from the fact that many chemicals have been used regularly over time without causing gross effects. However, in some cases effects are subtle and damage to the environment or to human health has only been discovered after large quantities of chemicals have been released." (p14, 1.5. 1999)”

The authors of Making sense of chemical stories also seem to be unfamiliar (perhaps unsympathetic) with the science of multiple chemical sensitivity. This is the science relating to the concept that at some point the total toxic load upon the body, which is mainly processed by the liver, may overwhelm the body's ability to detoxify and safely excrete excess chemicals, whether natural or synthetic. The use of certain nutrients to be utilized in these processes – notably antioxidants, minerals and amino acids - are ‘limiting factors' affecting an individual's detoxification capacity and chemical clearance rates. Detoxification is far more than just drinking tap water, contrary to the SAS claim. 1-30

Many synthetic chemicals are inherently toxic “by nature”, so to speak, so that their safety profiles are typically worse than natural products. Controlled substances are regulated so tightly precisely because of their potential for causing bodily harm. While natural products may occasionally have this potential, as a general rule experience shows that they are less toxic than drugs, which are typically made from synthesized chemicals. 31 This safety for natural products is borne out by statistics from the American Association of Poison Control Centers. 32

The Sense About Science authors ignore the persistence of man-made chemicals in the environment, including people's bodies. The European Environment Agency has released a report called Europe's environment: the third assessment (2003) that makes a couple of relevant points on this topic:

Although hexachlorobenzene (HCB) emissions have decreased throughout Europe, the rate of decrease has slowed markedly since 1990. HCB remains widely dispersed throughout the region due to long-range atmospheric transport processes and local ‘hot spots' that reflect high levels of local use or contamination.

There is concern over the dispersion of polybrominated flame retardants in the environment. Concentrations have risen steeply in Swedish human milk since the 1970s, despite these substances never having been manufactured in that country. Although concentrations are now declining, they remain many times higher than those in the 1970s.
In one part of its report, the SAS lists a number of chemical compounds that are in green tea by their long chemical names. The point is that we shouldn't fear chemicals just because they have unfamiliar, scary names. Fair enough, but why shouldn't we fear man-made chemicals that have not been used safely for thousands of years as components of common foods? This is the kind of misleading argument that the report repeatedly resorts to, exploiting the ignorance of the intended audiences: the media and the public. I don't see green tea on the EPA's Toxic Release Inventory report, but I do see chemicals that the SAS report seem to be positioning as safer than food, in some cases.

In the case of St. John's wort, the authors are mistaken in saying (in a pre-release interview) that, since we do not know what its active ingredient is, you cannot assess its dosage. Quite the contrary, there is a therapeutic monograph on the use of this herb on www.herbalgram.org, as well as a good body of science. 33-36

The identification of an active component has never been the sole determinant of the use of herbs, even at the point when herbs were the predominant therapeutics listed in medical reference works prior to World War II. The search for an active component is a mindset that's more pharmaceutical than nutraceutical, betraying an institutional bias against unpatentable natural substances. Valuing the native genius of nature means realizing that a whole herb may be gentler and more balanced than is a constituent molecule with a specific drug-like action. Think aspirin versus white willow bark: the herb does not commonly cause stomach bleeding, as the isolated drug –even as the acetylated form – usually does.

The fact that St. John's wort may interact with some drugs should not be considered a serious flaw, as the SAS people implied. A commonly used warning statement on the label of St. John's wort products gives adequate cautions about possible interactions. 37 Common foods and spices like ginger, garlic and grapefruit also can interact with drugs, yet where are the scientists complaining about these products?

For an article coming from a non-profit group that purportedly exists to promote evidence-based science, I find their arguments to be unconvincing and unrepresentative of the whole body of facts. The presence of nutrients and other compounds, including trace elements, in food and food supplements is crucial to the process of detoxification. The role of natural nutrients to help reduce the total toxic load is essential to our understanding of the body's detoxification capacity and processes.

I believe that ‘natural is better', because nature has a wisdom in producing chemicals and our bodies have adapted to their presence. Many of these are essential to life. I have seen many, many examples of this in the published scientific literature. Nothing in the SAS report convinces me that I should prefer being exposed to the not-quite-identical man-made versions of naturally occurring chemicals or totally synthetic, environmentally persistent, man-made chemicals. The SAS promises to use scientific evidence in its reporting, but my review of the research convinces me that this promise was inadequately kept regarding its report titled ‘Making sense of chemical stories'.

Neil E. Levin Certified Clinical Nutritionist Diplomate in Advanced Nutritional Laboratory Assessment

Bloomingdale, IL USA


REFERENCES:

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12 McFadden SA. Phenotypic variation in zenobiotic metabolism and adverse envirnomental response: focus on sulfur-dependent detoxification pathways. Toxicology 1996;111:43-65.

13 Miners JO, Mackenzie PI. Drug glucuronidation in humans. Pharmacol Ther 1991;51:347-369.

14 Brockmöller J, Roots I. The assessment of metabolic function. Clin Pharmacokinet 1994;27(3):216-48.

15 Jost G, Wahlländer A, von Mandach U, Preisig R. Overnight salivary caffeine clearance: a liver function test suitable for routine use. Hepatology 1987;7(2):338-44.

16 Renner E, Wietholtz H, Huguenin P, Arnaud MJ, Preisig R. Caffeine: a model compound for measuring liver function. Hepatology 1984;4(1):38-46.

17 Scavone JM, Greenblatt DJ, LeDuc BW, Blyden GT, Luna BG, Harmatz JS. Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation. Pharmacology 1990;40:77-84.

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19 Patel DK, Ogunbona A, Notarianni, Bennett PN. Depletion of plasma glycine and effect of glycine by mouth on salicylate metabolism during aspirin overdose. Human Exp Toxicol 1990;9:389-95.

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21 Steventon GB, Heafield MTE, Waring RH, Williams AS, Sturman S, Green M. Metabolism of low-dose paracetamol in patients with chronic neurological disease. Xenobiotica 1990;20(1):117-22.

22 Steventon GB, Heafield MT, Waring RH, Williams AC. Xenobiotic metabolism in Parkinson's disease. Neurology 1989;39:883-7.

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24 Krijgsheld KR, Mulder GJ. The availability of inorganic sulfate as a rate-limiting factor in the sulfation of xenobiotics in mammals in vivo. In: Mulder GJ, et al., eds., Sulfate metabolism and sulfate conjugation. London: Taylor and Francis, 1982: 59.

25 Heafield MT, Fearn S, Steveton GB, Waring RH, Williams AC, Sturman SG. Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease. Neuroscience Letters 1990;110:216-20.

26 Oguro T, Gregus Z, Madhu C, Liu L, Klaassen CD. Molybdate depletes hepatic 3-phosphoadenosine 5-phosphosulfate and impairs the sulfation of acetaminophen in rats. J Pharmacol Experimental Therapeut 1994; 270(3):1145-51.

27 Corcoran GB, Racz WJ, Smith CV, Mitchell JR. Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice. J Pharmacol Experimental Therapeut 1985; 232(3):864-72.

28 Smilkstein MJ, Douglas DR, Daya MR. Acetaminophen poisoning and liver function [letter]. N Engl J Med 1994;(Nov 10):1310-11.

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31 (Average 1982-1998): According to Canadian researchers, approximately 32,000 hospitalized patients (and possibly as many as 106,000) in the USA die each year because of adverse reactions to their prescribed medications. Source: Lazarou, J, Pomeranz, BH, Corey, PN, "Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies," Journal of the American Medical Association (Chicago, IL: American Medical Association, 1998), 1998;279:1200-1205, also letters column, "Adverse Drug Reactions in Hospitalized Patients," JAMA (Chicago, IL: AMA, 1998), Nov. 25, 1998, Vol. 280, No. 20, from the web , last accessed Feb. 12, 2001.

32 WATSON ET AL 2003 AAPCC ANNUAL REPORT The American Journal of Emergency Medicine (22(5):335-404, 2004)

33 Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS, editors. Klein S, Rister RS (trans.). The Complete German Commission E Monographs—Therapeutic Guide to Herbal Medicines. Austin (TX): American Botanical Council; Boston (MA): Integrative Medicine Communication; 1998.

34 Wheatley D. LI 160, an extract of St. John's wort, versus amitriptyline, in mildly to moderately depressed outpatients-a controlled 6 week clinical trial. Pharmacopsychiatry 1997; 30(suppl.):77–80.

35 Woelk H. Comparison of St. John's wort and imipramine for treating depression: randomized controlled trial. BMJ 2000 Sep;321:536–9.

36 A total of 11 studies have compared SJW preparations with conventional antidepressants (7 tricyclic; 4 SSRI) concluding that SJW is effective for mild to moderate depression with a low side effect profile (Kasper, 2001). (Herbalgram) Kasper S. Hypericum perforatum– Review of clinical studies. Pharmacopsychiatry 2001;34 Suppl. 1:S51–5.

37 Warnings: Do not exceed 3 capsules daily, unless directed by a health care professional. Larger amounts may contribute to photosensitizing reactions (skin reddening) in the presence of strong sunlight or tanning beds. If you are presently taking MAO-inhibitors or other anti-depressant medication, consult your health care professional prior to use.

 


posted by Sepp Hasslberger on Saturday January 28 2006
updated on Thursday December 16 2010

URL of this article:
http://www.communicationagents.com/sepp/2006/01/28/chemicals_better_than_nature_perhaps_not.htm

 


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Readers' Comments


Great coverage of chemical harm to public. I also have a section on my web site - "Chemicals and Pesticides" which includes an article on "Chemical Sensitivities."
Back in the 1960's I had many vaccinations to go overseas, which left me in poor health. I have been told that this probably was the result the overexposure to mercury (I had over a dozen 'shots' in just a couple of weeks), and I have been extremely sensitive to many chemicals since then. This has restricted my travel and keeps me ill much of the time.
Thanks for the info on your e-mails and web site!
June Russell

Posted by: June Russell on January 29, 2006 03:26 AM

 















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