Health Supreme by Sepp Hasslberger

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September 09, 2008

Diabetes - Why Vitamin C is important

Diabetes has become a veritable epidemic in the affluent Western world. According to the Centers for Disease Control and Prevention, an estimated 20.8 million persons in the United States, or about 7 percent of the population, has diabetes, although the illness had been diagnosed in only about two thirds of these people.


Some say that diabetes is an incurable disease - Amputee Coalition of America

The problem is one of glucose metabolism, says Beldeu Singh, and the major problem, apart from a widespread over-consumption of sugars, is that in the presence of excess free radical activity, glucose is transformed into sorbitol. Normally, sorbitol is then transformed into fructose, which our bodies can use. In the presence of free radicals however, sorbitol degrades into toxic metabolites.

Pharmaceutical drugs turn our bodies into an environment of high free radical activity. So widespread (pharmaceutical) drug use may very well have something to do with the epidemic of impaired glucose metabolism we see. Antioxidants counter-act free radical activity, but our stores of vitamin C, the antioxidant par excellence, are soon depleted and the recommended 60 to 180 milligrams are insufficient to turn the situation around. It is tempting to say that what we see is actually an epidemic of vitamin C deficiency, rather than an epidemic of diabetes.

Beldeu Singh has written down the information on metabolic pathways involving sugars and insulin in his article

Diabetes - A Glucose Metabolism Problem
(PDF available here)

Some extracts relevant to the discussion of vitamin C:

Part of the problem biochemistry in diabetics starts with reduced ability of insulin to bind at its receptor sites on cell surfaces. Oxidatively damaged insulin molecules cannot bind to their receptor sites to facilitate the entry of glucose into the cells where it is routed into the pathway to yield energy. Instead, sorbitol accumulation takes place in the cells of diabetic patients, known to be associated with chronic complications in diabetic patients. A high dose vitamin C (2000mg per day) has been shown to reduce the accumulation of sorbitol. The antioxidant vitamin C is known to suppress the polyol pathway activity induced by high glucose but why are such high doses necessary? In plasma, ascorbate maintains its antioxidant activity, even at very high concentrations. In most species, cells in the liver produce L-ascorbic acid from metabolism of glucose through the glucoronic pathway. In man, however, the absence of one enzyme in that pathway necessitates the dietary intake of a micronutrient, termed vitamin C, to prevent scurvy and oxidative stress that relates to insulin and its ability to bind at its receptor sites on the cell surface.

The key factor in L-ascorbic acid dietary intake is the fact that vitamin C entry into cells is insulin mediated and consequently, diabetics do not have sufficient L-ascorbic acid in their cells. This chronic deficiency of vitamin C within the cells in diabetic patients despite adequate intake as per normal standards does not help them as much as a very high intake and the prolonged deficiency of vitamin C in the diabetic is problematic and leads to vascular disorders, elevated blood cholesterol and depression of the immune system.

High doses of L-ascorbic acids and a broad range of dietary antioxidants become important to initiate biological repair to improve healthy biochemistry. Recent studies reveal that high dose vitamin C, alone can provide an effective means of correcting sorbitol accumulation than current pharmaceutical approaches. The role of L-ascorbic acid may lie in its ability to inhibit aldose reductase as well as its ability as an antioxidant to drive the antioxidant-driven pathway that converts sorbitol into fructose by promoting the activity of sorbitol dehydrogenase. The polyol pathway is a two-step metabolic pathway in which glucose is reduced to sorbitol, which is then converted to fructose.

And again, you can get and read the whole article here.

Other articles by the same author available on this site are listed here (scroll down to find the listing)...


posted by Sepp Hasslberger on Tuesday September 9 2008

URL of this article:


Related Articles

Researchers: Vitamin C Deficiency Widespread - Link to Heart Disease, Infections, Cancer
In their book "Ascorbate - The Science of Vitamin C", Steve Hickey PhD and Hilary Roberts PhD point out that deficiency of vitamin C is far more widespread than is generally acknowledged by medical doctors and dieticians today. The two scientists, specialized in medical biophysics and nutrition, have challenged the scientific basis of the recommended daily amounts for this vitamin with medical authorities including the NIH - the National Institutes... [read more]
July 09, 2004 - Sepp Hasslberger

Overcoming Aids, Infections, Heart Disease: Vitamin C Is Key
Vitamin C may be a life-saver, wrote Jane Feinmann in a recent article in The Independent, one of the major papers in the UK. According to the article, in June 1949 when polio was at its peak. Dr Frederick Klenner, a clinical researcher from Reidsville, North Carolina, reported that a massive intravenous dose of Vitamin C - up to 20,000mg daily for three days (today's recommended daily allowance is 60mg)... [read more]
April 22, 2005 - Sepp Hasslberger

Better Than A Flu Shot - Vitamin C Does The Trick
The flu season is upon us another time with a vengeance. This year, we have a special propaganda bonus - the bird flu - although it has very little to do with the flu that gives us the sniffles in any normal year. There is no vaccine for the bird flu because it is a bird virus that "has not yet mutated to be transmitted between humans" but we are... [read more]
November 14, 2005 - Sepp Hasslberger

From Avoiding Deficiency to Optimal Health - RDA Focus 'Must Change'
Nutrition is of course what happens when we eat, but there is a very scientific side to nutrition that counts infinitesimal quantities of certain vital substances. Without these vital 'vitamins' and minerals we just can't survive. Our bodies fall ill and refuse to function. Those are serious deficiency diseases like scurvy, a sure killer that comes after weeks and months of little or no vitamin C. Nothing like an orange... [read more]
August 30, 2008 - Sepp Hasslberger

Cancer: Intravenous Vitamin C Effective Treatment
Studies during the 1970s first suggested administration of high doses of ascorbate might provide a clinical benefit for treating cancer, but later studies using the same high doses found no benefit. However, researchers now say the original studies used intravenous and oral ascorbate, while subsequent studies used only oral administration. Recognizing those differences might account for the disparate clinical outcomes, Mark Levine and colleagues at the National Institutes of Health... [read more]
September 13, 2005 - Sepp Hasslberger

Depleted Uranium Doubled Diabetes Rate: Leuren Moret
Depleted Uranium has been used in bombs and armour piercing munitions by the US-led war machine for about two decades, with great increases in the Iraq wars, in Afghanistan and the Balkans, and more recently also in Lebanon. But the uranium spread around the battle fields as a fine dust does not stay where it was released. It spreads around the planet and causes - says Leuren Moret - a... [read more]
September 28, 2006 - Sepp Hasslberger




Readers' Comments

yes, vit c saved sailors from scurvy.the whole fruit. the sunkissed california fruit,the pulp,fibre,skin marmalade, all all included. NOT JUST the refined /extract juice. =there are many other sour juicy fruit loaded w vit C 50mg in nature, picked and eaten uncooked , raw. like Guava. good for the masseter jaw chew muscles, for the gums,ripe for the aromatic alDehydes. Never the cheaper synthetic 500mg tablets, for use only when the real is out of reach.

Posted by: dr george pradhan mb, ind on September 21, 2008 03:58 AM


Vitamin c gives a hand in the production of collagen, that type of protein that gives strength to your body bones, muscles, ligaments, cartilages, blood vessels and teeth.

Posted by: albert on January 13, 2009 08:23 AM


I believe vitamin c could cure or at least could lessen the effect of diabetes. I did some research about this. One of the things that I want to share is there is at least one testimony by lypo-spheric vitamin c user, he said he no longer taking 'metformin' after taking this high quality lypo-spheric vitamin c. Do you have any user testimony (about the good effect of vitamin c) to share?

Posted by: lypo-spheric vitamin c on August 26, 2009 12:47 AM


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These articles are brought to you strictly for educational and informational purposes. Be sure to consult your health practitioner of choice before utilizing any of the information to cure or mitigate disease. Any copyrighted material cited is used strictly in a non commercial way and in accordance with the "fair use" doctrine.



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