Health Supreme by Sepp Hasslberger

Networking For A Better Future - News and perspectives you may not find in the media

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August 24, 2005

Immunoglobulin-Based Biochips:Next Diagnostic Revolution

Biochips have been used for years in gene research, for the purpose of DNA sequencing and testing, but there may be a more mundane use and one of more immediate application - automating blood and urine testing for diagnostic purposes.

"A biochip is a collection of miniaturized test sites (microarrays) arranged on a solid substrate that permits many tests to be performed at the same time in order to achieve higher throughput and speed. Typically, a biochip's surface area is no larger than a fingernail. Like a computer chip that can perform millions of mathematical operations in one second, a biochip can perform thousands of biological reactions, such as decoding genes, in a few seconds."

While use in diagnostic testing is hypothesized, we are still largely in the area of gene screening, according to an article in "Hospital Practice". Perhaps automating "normal" diagnostic tests is seen as financially unwise? Arguably, it would put today's diagnostic business in a turmoil.

Keep the genie in the bottle seems to be the motto. IBC Life Sciences is a specialized research and communications company that offers a range of services to pharmaceutical manufacturers, including biochip development and new-drug research. Having organized yearly conferences on biochip technology since 2001, the company has surprisingly cancelled the 2005 BioChips conference. They do ask for feedback on this form to see what professionals would like their conference to be looking into.

Meanwhile however, Russian scientists seem to be progressing well in the diagnostics field, according to an article by Yuri Amosov and others.

- - -

Innovation Success Stories - Part II

By Yuri Amosov, Irik Imamutdinov, Galina Kostina, and Dan Medovnikov

Originally found on

Western venture capitalists repeatedly declared their genuine interest in Russian scientists and researchers but had no dealings with them, at least not in Russia itself. Many good innovation projects failed to become investment projects. Things seem to have changed this time.

Biochips, not labs

The Immunoglobulin-Based Biochips project was recognized as the Most Promising Project. The creation of biochips - micro-units screening for a vast array of human diseases - is a revolutionary achievement in biotechnology of recent years. A biochip in the form of a tiny plastic plate (5-10 mm across) holding up to several thousand different micro-tests, enables medical practitioners to detect several thousand pathogens, allergens, carcinogens, biologically active substances from medicines to drugs, and genetic defects all at the same time. The technology of protein biochips could replace entire immunology laboratories and increase the productivity of most diagnostic methods by thousands or even tens of thousands of times, radically reducing the cost of medical tests.

Although the first protein biochips were created back in the early 1990s, researchers began to deal with them most actively in the last three years. Scientists from the Hematology Research Center at the Russian Academy of Medical Sciences in conjunction with the Russian Academy of Sciences Institute of Theoretical and Experimental Biophysics are working on a set of devices that produce biochips and monitor their quality, as well as instruments and software for reading the biochip.

One of the innovators' main scientific achievements is a method for applying protein solution to a matrix. Instead of the usual application technique by tiny, automatic arms, the project proposes the electric evaporation method. It enables scientists to manufacture thousands of microchips at once and save on both protein solution and production time (1 mcl of the solution is sprayed onto 100,000 points for 30 seconds). In addition these microchips are much smaller than existing ones, which would reduce the costs of producing and reading the chips by several times.

For the time being, developers are focusing on biochips to detect infections of the urethra and genitals, as this market is huge. Given the value of biochips and biochip-related services, the outlay for production, market research, and advertising could be repaid in two years.

The potential applications for biochips go far beyond medicine. The chips can be used in environmental studies to detect hazardous substances or in criminal investigations to find drugs, poisons, or explosives and for personal identification purposes. After the project presentation at the competition, the promotion fund decided to finance it as part of the Start Program, and AFK Sistema awarded it a special bonus.

- - -

See also:

Microscopic brain imaging method developed

Testing the Waters
Sensicore has developed a "lab-on-a-chip" sensor that enables fast and inexpensive monitoring and profiling of water quality.

Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses
Nano-sized carbon tubes coated with strands of DNA can create tiny sensors with abilities to detect odors and tastes, according to researchers at the University of Pennsylvania and Monell Chemical Sciences Center. Their findings are published in the current issue of the journal Nano Letters, a publication of the American Chemical Society.

URI to develop 'lab-on-a-chip' technology
Imagine an entire biotechnology laboratory reduced to the size of a pea and placed on a computer chip. While not yet a reality, that technology for detecting small particles in micrometer-sized channels called microfluidics -- will soon revolutionize research into new pharmaceuticals, early detection of infections, and other health-related fields. The University of Rhode Island has been awarded a highly competitive $2.4 million grant by the National Science Foundation to develop this technology and identify potential applications in partnership with the Technical University of Braunschweig in Germany.

New Microlab on Chip for Medical Imaging Biomarkers
A collaboration among scientists at UCLA, the California Institute of Technology, Stanford, Siemens and Fluidigm has developed a new technology using integrated microfluidic chips for simplifying, lowering the cost and diversifying the types of molecules used to image the biology of disease with the medical imaging technology, positron emission tomography (PET).


posted by Sepp Hasslberger on Wednesday August 24 2005
updated on Sunday December 5 2010

URL of this article:


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Roots of Medical & Other Monopolies
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September 23, 2003 - Sepp Hasslberger

Gene Therapy may cause leukaemia
As reported in BBC health, scientists have run into trouble on gene therapy. The side effects appear to be serious. "a number of children developed leukaemia following gene therapy treatment. High profile gene therapy trials have been stopped in France and but are continuing in the UK despite a number of children developing leukaemia follwing treatment."... [read more]
June 03, 2003 - Sepp Hasslberger

The Avian Flu and Drugless Doctors
BBC carried an article on 5 February titled "1918 killer flu secrets revealed" which tells us that the scientists claim to now have figured out that 50 million people were killed by a virus that "jumped from birds to humans". Obviously this is to prepare us for a "killer epidemic", something that is supposed to hit any time now, be it this winter or the next or the one after... [read more]
February 07, 2004 - Sepp Hasslberger

Laser Light Kills Human Blood: Russian Scientist Warns
Psyquantum radiation in lasers kills human blood Could it be that lasers, in common use today in optical recording and playback devices, laser pointers and even medical devices, are actually harmful to human health? Leonid S. Vilenchik, director general of MDB Electron says that a new type of radiation has been found to that is emitted by lasers. It is a penetrating radiation that, according to experimental findings of his... [read more]
October 23, 2004 - Sepp Hasslberger




Readers' Comments

this information is not clear,whybecause this information do not give complete idea on bio chip

Posted by: sampath enukonda on August 30, 2005 10:51 AM


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These articles are brought to you strictly for educational and informational purposes. Be sure to consult your health practitioner of choice before utilizing any of the information to cure or mitigate disease. Any copyrighted material cited is used strictly in a non commercial way and in accordance with the "fair use" doctrine.



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