Health Supreme by Sepp Hasslberger

Networking For A Better Future - News and perspectives you may not find in the media

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July 10, 2007

Low Dose Naltrexone in AIDS, Cancer and Autoimmune Diseases

Low dose naltrexone (LDN) is a promising treatment for autism, Aids, cancer and autoimmune diseases. The costs are negligible and proponents say that the drug could help many, but clinical trials aren't in the interests of pharmaceutical manufacturers. Without further studies, there is no way to find how this drug supports the immune system.


Naltrexone in MS - Image: Auburn Journal.

Naltrexone is a drug that blocks the effects of opiate drugs and it was approved by the US FDA in 1984 for the treatment of addiction. Dr George O'Neil in Perth, Australia, has been very successful in treating addiction with naltrexone implants, a slow release form of the drug implanted under the skin, that will keep an addict free from the desire for the next fix for anywhere from three to six months. Usually this allows enough time for de-toxification and for a change in life circumstances, where the former addict can stay free of drugs even after the implant's effect wears off.

For the treatment of drug addiction, the usual dose of naltrexone is 50 mg per tablet but there is another use of the drug that seems not to have been found by the original research: In a low dose of 3 to 4.5 mg (milligrams), naltrexone acts to straighten out the immune system and to fight a wide range of diseases involving a immune malfunctions. In AIDS, low dose naltrexone (LDN) has been given by Dr. Bihari alone or together with the standard anti-retroviral treatment, with excellent results in both cases.

Jaquelyn McCandless and Jack Zimmerman are planning to extend that experimentation now, and they have set up a Yahoo Group (LDN in HIV AIDS) to share information about the trial and eventual outcomes. Here is the introductory message explaining what they are about to do:

- - -

LDN in HIVAIDS Yahoo Group

The LDN in HIVAIDS e-group is for those interested in use of low-dose naltrexone (LDN) in HIV+AIDS as carriers, those related to carriers, caretakers, health professionals or other helpers in the field. Autism as AIDS is a disorder of immune regulation; as an autism specialist, I found in an immune study in 2005 that LDN raised the CD4+ count in 16 weeks in the majority of autistic children and their parents. This and other information about LDN led me to take on coordination of a research study in Mali instigated several years ago by Dr. Bernard Bihari, the discoverer in 1985 of LDN’s beneficial effect in HIV+AIDS. The purpose of the clinical study is to investigate this drug’s effectiveness in preventing the progression of HIV+ status to full-blown AIDS.

LDN will be compared to HAART drugs and a group using both is part of the study; no placebos are to be used in this project.

I visited Mali with my husband Dr. Jack Zimmerman in December 2006 to meet the investigational team and inspect the laboratory facilities at the University of Bamako University Hospital where the study will take place. Jack is coordinating the social/cultural aspect of the study to help educate and use council groups for the participants on issues around HIV infectivity, gender imbalance being particularly important in the case of females who are increasingly and disproportionately being affected by the disease. Though we are still fund-raising, we are confident enough to go ahead and start the study; the 16 counselors started their council course on May 2-4, being taught by experienced trainers in council from South Africa. The IRB is being finalized soon, after which our research team will begin recruiting and evaluating the 250 participants for the study. We are planning to start the first group (20 will start each week until full) in mid-July. We are here to share and learn about LDN; welcome to all!!

Jaquelyn McCandless M.D. and Jack Zimmerman, PhD

Side effects

According to this site, LDN has virtually no side effects. Occasionally, during the first week's use of LDN, patients may complain of some difficulty sleeping. This effect rarely persists after the first week and can usually be remedied, should it do so, by reducing the nightly dosage from 4.5mg to 3mg.

I am not one to advocate the use of medication and believe that proper nutrition and supplementation of vital elements as suggested by Dr. Harold Foster, should be the first choice for anyone testing positive on an 'HIV' test. But if AIDS sufferers can be spared at least some of the agony they experience when undergoing treatment with anti-retroviral drugs, and have better health outcomes to boot, it would appear a very worthwhile thing to substitute LDN for the rather damaging cocktail of toxic drugs given to anyone with a positive 'HIV' test.

LDN and Cancer

Here again, Dr. Bihari reports that giving low dose naltrexone to cancer patients, almost all of them having failed to respond to standard treatment, more than 60 % experienced substantial benefits. Types of cancer that responded, according to Dr. Bihari, to LDN treatment include

* Bladder Cancer

* Breast Cancer

* Carcinoid

* Colon & Rectal Cancer

* Glioblastoma

* Liver Cancer

* Lung Cancer (Non-Small Cell)

* Lymphocytic Leukemia (chronic)

* Lymphoma (Hodgkin's and Non-Hodgkin's)

* Malignant Melanoma

* Multiple Myeloma

* Neuroblastoma

* Ovarian Cancer

* Pancreatic Cancer

* Prostate Cancer (untreated)

* Renal Cell Carcinoma

* Throat Cancer

* Uterine Cancer

Low dose naltrexone has also been used with surprising results on some patients suffering from Multiple Sclerosis.

Autoimmune diseases that have responded to LDN treatment are lupus, rheumatoid arthritis, Behcet's syndrome, Wegener's granulomatosis, bullous pemphigoid, psoriasis, and Crohn's disease.

Because LDN clearly halts progression in multiple sclerosis, its use has been more recently extended to other neurodegenerative diseases, such as Parkinson's disease and amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) whose etiology remains unknown but for which there is suggestive evidence of a possible autoimmune mechanism.

In addition, people with fibromyalgia and chronic fatigue syndrome have had marked improvement using LDN, suggesting that these entities probably have an important autoimmune dynamic as well.

Perhaps I should add that naltrexone is not an expensive medication. There is a generic version, and low dose naltrexone can either be obtained by fracturing the 50 mg tablets, or it can be compounded in pharmacies.

What is missing are formal clinical trials for all the uses of LDN, but there is no great chance that a pharmaceutical company will embrace the treatment and perform the experiments, as little money is to be made from it. Better to sell expensive patented anti-retrovirals than a simple drug that is cheap to make, at least if we look at the pharmaceutical bottom line. It is a great pity, but this is how things work in our economic environment. If a pharmaceutical drug is not promising to bring in at least millions, it will at best be tolerated. Should a cheap drug interfere with other, more lucrative treatments, well ... I don't need to spell that out for you.

So if you are a medical doctor or are interested in any way in helping those suffering from AIDS and a series of other immune-related diseases, you might do well to get in contact with Jaquelyn McCandless M.D. through her yahoo group discussing the upcoming trial. Perhaps you can contribute to sneaking this promising treatment past pharma's guard dogs...

Related websites:

Low Dose Naltrexone

Low Dose Naltrexone for Multiple Sclerosis

Protocol for Low-Dose Naltrexone for Cancer


posted by Sepp Hasslberger on Tuesday July 10 2007

URL of this article:


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Readers' Comments

Croft asked (by email):

Sepp: But, what are they doing about drugs for malaria, TB, parasitic infections, etc., and ensuring the people have access to solid nutrition, potable water, proper shelter and sanitation? How much does this drug Naltrexone cost per dose? Who makes it?
My reply: this is not a pharmaceutically sponsored trial but a husband and wife team organizing the study of low dose naltrexone on Aids patients in Mali. I don't think they have much time left over to do something about all the other problems you list, at least that doesn't seem to be their focus. Naltrexone is not too expensive, at least in comparison with the HAART drugs it could potentially replace. Here is a paragraph that discusses the price of compounded 4.5 mg naltrexone:
"One of the first pharmacies to do so was Irmat Pharmacy in Manhattan. Their recent price for a one-month's supply of 4.5mg LDN (30 capsules) was $38. Irmat does monthly quality control testing on its LDN, accepts prescriptions from any licensed physician, checks for insurance coverage, and includes shipment anywhere in the US or to other countries. In contrast, Gideon's Drugs charges $15 for a one month's supply of 4.5mg LDN but it does not accept insurance and it will charge for shipment."
Who makes the drug:
"Naltrexone in the large 50mg size, originally manufactured by DuPont under the brand name ReVia, is now sold by Mallinckrodt as Depade and by Barr Laboratories under the generic name naltrexone."
( both quotes are from ) Sepp

Posted by: Sepp for Croft Woodruff on July 10, 2007 01:01 PM


I'm glad to see yet another GREAT post about LDN. I'm Vicki, the one in the picture. I have been on LDN for a year and 8 months and I'm still doing very well and still advocating for this drug. It's very frustrating that a drug like LDN which shows great promise in treating diseases doesn't get more recognization. The reason is it's cost. LDN is about a dollar a day, safe, really doesn't have any side effects and works in a good percentage of sufferers. Ask yourself why more doctors and our Government wouldn't insist on more research!!! My belief is money, honestly there isn't any money to be made in this drug it's a shame money is far more important that our lives. I have written to several people only to get no response. I will continue to advocate for LDN, had I not found LDN when I did, I too would have been in a wheelchair now I'm living proof along with the thousand other MS sufferers that LDN works and needs the attention. Thank you for helping us spread the word about LDN we need more people and sites to educate others!!!! Vicki Finlayson

Posted by: Vicki Finlayson on July 11, 2007 10:26 AM


Thank you for your comment Vicki, the drug certainly seems to be an interesting way of getting the better of a whole slew of illnesses. Probably a completely unintended effect. Yes, it is up to people like you and Dr McCandless and a few sites like this one, as the media seem reluctant to touch the story and certainly the pharmaceutical companies don't like angering their investors by promoting cheap and effective medications.

Posted by: Sepp on July 12, 2007 05:35 AM


Naltrexone (LDN)is a promosing treatment, but clinical trials aren't in the interests of pharmaceutical manufacturers. Without further studies, there is no way to find how this drug supports the immune system..pharmaceutical company set aside this drug,because they will not gain any huge profit when several types of cancer/illness will be cured, it might also cured hepatitis B carrier HBV, so therefore better not to produce this drugs that can cure..inorder to gain miilions or billions of $ in profit

Posted by: Archie on July 20, 2007 07:30 AM


Narcan: FDA approved since 1984 Narcan, also called Naltrexone, has been FDA approved since 1984 for reversal of narcotics overdose. It reverses the sedating effect of opiates by binding to the opioid receptors in the brain. Narcan is available in the hospital operating room where anesthesiologists use it to wake up the patient after the operation. It was a surprise for me to find out that this commonly used drug has other very important uses at a much lower dosage as an oral capsule. Medical scientists have been carefully studying its effect on the immune system, and its clinical benefits for a host of disease states for the past 20 years. Low Dose Naltrexone, (LDN), How Does it Work? The beneficial effect of low dose naltrexone, LDN, was discovered by Bernard Bihari, MD, a physician in New York City who found that a small dose (3 mg) of naltrexone taken as a capsule at bedtime blocks the opiate receptors in the brain for a few hours during sleep, which then stimulates the brain to increase production of endorphins over the next 24 hours. These endorphins then stimulate the immune system. Although Bihari did much of the early clinical work, Zagon did much of the groundwork with animal research studies at Pennsylvania State University. LDN Cures Crohn's Disease A recent publication in the Jan 2007 Journal of Gasteroenterology on the use of LDN in Crohn's Disease, was the first breakthrough publication to appear entitled, Low-Dose Naltrexone Therapy Improves Active Crohn's Disease by Jill Smith MD. For a more complete review of see my newsletter: Low Dose Naltrexone (LDN) by Jeffrey Dach MD

Posted by: Jeffrey Dach MD on August 5, 2007 07:28 AM


Naltrexone may possibly work because it affects methylation in the body?

S-adenosylmethionine (SAM) is a vital component for methylation and Naltrexone has a beneficial effect on it's levels.

"The beneficial effect of naltrexone may be due to its ability to increase liver SAM level and restore the SAM : SAH ratio."
Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis

I wrote about methylation amd these diseases here.

Why Retroviruses Appear in AIDS, Cancer and Autoimmune Diseases

My thoughts anyway

Posted by: Cal Crilly on August 19, 2007 08:34 PM


A booklet featuring 5 Multiple Sclerosis (MS) health success stories attributed to LDN is available from casehealth.

The stories were extracted from the casehealth online database collection.

The booklet is free and can be shared-forward under the same philosophy.

Kind regards,

Posted by: Cris on January 27, 2008 08:44 PM


Aids, Herpes 1&2 Hepititis A-B-C, Fungi and many other Viral or Bacterial invaders can be easly removed from your body with Jim Humbles Discovery of MMS. My web Blog is full of health info. Scroll down to article on Update on MMS and FrequenSea and read it to find out all about MMS, or go to Good luck

Posted by: Mel Smith on April 23, 2008 11:45 AM


Naltrexone is one option. I stopped my autoimmune disease (MS) naturally.

There are ways to harmonize and reinforce immune system without drugs. That usually works better.

Posted by: Czes Kulvis on July 16, 2008 07:28 PM


I'm pleased to announce the 2010 edition of my free low dose naltrexone (LDN) resource book 'Those Who Suffer Much, Know Much' is now available online. You'll find an explanatory article, 51 patient case histories, 19 health professional interviews and perspectives, related research and references in this comprehensive 2010 updated edition: 'Those Who Suffer Much, Know Much' 2010 edition All my best, Cris Kerr

Posted by: Cris Kerr on August 20, 2010 05:28 PM


ARV drugs do not cure people of the HIV virus or AIDS, they only make people sick. Most people do not realize that ARV drugs actually feed the HIV virus so that the virus doesn't go into full blown AIDS and consume the entire body. Thus, ARV drugs keep one alive but at the expense of immense pain and suffering, feeding the virus their happiness and energy. Listen to the audios to see how Aids is being cured without drugs.


Posted by: ida on June 6, 2011 12:46 PM


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The Individual Is Supreme And Finds Its Way Through Intuition


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