Health Supreme by Sepp Hasslberger

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June 30, 2003

Polypill - miracle cure or insanity?

28 June 2003 - The mainstream British Medical Journal announced in an editorial that a "magic bullet" combination pill containing aspirin, a statin, three blood pressure lowering agents in half dose, and folic acid could have enormous potential, especially in developing countries.

The story had previously been published in New Scientist.

Should we really throw out all we know about medicine and research for this pharmaceutical moneymaker?

According to an article in the Fresno Bee, "the American Heart Association cautioned such a pill might be dangerous for healthy people and not strong enough for those with heart trouble."

Others agree that the idea is a dangerous departure from sanity.

Update on 30 June 2003:

One of the ingredients in this proposed new wonder drug is a statin. Here is a page with information about and the dangers they pose to health. I wonder whether, in assessing and adding together the supposed positive effects, the scientists who made this proposal have also thought of adding up the side effects of their ingredients and the probabilities of causing death in unsuspecting patients.

RED FLAGS WEEKLY editor Nicholas Regush wrote:

THE POLYPILL

This is the brazen idea being promoted by UK researchers to slash heart attacks and strokes. As the New Scientist puts it, "a wonder pill that could slash the rate of deaths from heart attack or stroke by over 80 per cent." Another round in the dumbing down of medical science as we know it.

There are two articles you might read:

THE NEW SCIENTIST NEWS STORY

AN EDITORIAL IN THE BRITISH MEDICAL JOURNAL

What is this wonder pill all about? It's the idea of a combination pill that everyone over the age of 55 (or younger) would take - and could reduce the incidence of cardiovascular disease by over 80%.

Is there actual data for this humdinger? No, there is not. The authors propose this idea based on a review of other studies, and strangely believe that the data all could add up to a huge reduction in the incidence of cardiovascular disease.

This has got to be one the dumbest ideas that I have ever come across in all my years as a health reporter. That the authors actually have the support of the British Medical Journal is truly amazing and dangerous. All these so-called health professionals actually have convinced themselves that if you put six different drugs together, they will all add up to one big cure of sorts. This is not only junk science at its worst, but reveals the sloppy intellectual processes going on in focusing attention on such complex issues (and controversial ones, I might add) surrounding cardiovascular disease. Furthermore, to assume that each and every one of these drugs used for different purposes in the battle against heart disease is, for one thing, the best approach in providing treatment for heart trouble, and then to assume that you can batch them, on the basis of what they appear to be doing on their own, is fool's gold. It's also nutty, and frankly, you can't get nuttier than that in medical science, particularly when you don't have a scratch of evidence that such a polypill will be safe and effective. There is simply no evidence worth anything - and I mean anything - that this approach can work to reduce heart disease. This blatant move to incorporate a variety of theories about cardiovascular disease into one package reveals a total disregard for scientific principles and for the human condition, which is far more complex than these nutty researchers seem to think. They all need to go back to school and get themselves properly educated. They should be sharpening pencils in some back room rather than using other people's money to do research not worth a dime.


An incredulous friend from Ireland says

Yesterday we read that antioxidants reduce the risk of cancer by 31%.

Today we read that the BMJ has launched the 'Polypill' which "is like vaccination in a community that has the disease all over the place". 

For those of you who haven't read about it yet, this pill offers the over-55s an average extra 11 years of life free from a heart attack or stroke. We are now being offered this wonderful pharma innovation of a combination "for only £ 1 per day" of aspirin, a cholesterol-lowering drug, three drugs that lower blood pressure and folic acid! It is being claimed that this pill could have "a greater impact on the prevention (prevention???) of disease in the Western world than any other known intervention". This pill is being touted as "medicine's answer to man's frailty", because although the same effect could be obtained from eating a diet of fruit and veg, taking exercise and giving up cigarettes, "changing the total diet of the nation is really quite impractical". All this from Prof. Wald of the Wolfson Institute of Preventative Medicine, University of London.

Thrown in for good measure is his comment: "At least a third of adults already took daily pills in the shape of vitamin supplements which had uncertain benefits."


And here a more detailed comment from US based health journalist Bill Sardi

British Doctors Claim Polypill (6-drugs-in-one-tablet) Would Reduce Cardiovascular Risk by 80%; Good Multivitamin Would Accomplish More Without The Cost And Side Effects

Without a clinical trial, and borrowing from science that has already been conducted, British researchers claimed today that "a once-a-day pill for everyone over 55 could undo some of the ill-effects of a sedentary, high-cholesterol, western lifestyle and slash the rate of strokes and heart attacks by more than 80%." [Guardian June 27, 2003; British Medical Journal Volume 326, June 28, 2003]

Known as the "polypill," it would combine five drugs (cholesterol-lowering statin drug, diuretic water pill, calcium blocker, blood pressure pill, aspirin) and one vitamin (folic acid) in a combo vita-drug that could put cardiologists out of business, says the editor of the British Medical Journal which published the report yesterday.

Calling its current issue "the most important in 50 years," the British Medical Journal heralded this bold approach even before it has been proven.

The authors of the polypill concept, who have filed for a patent on their idea, claim it might add as much as 11 years of life to the over-55 population by preventing strokes and heart attacks. The life lengthening benefits of the polypill are questioned in some regards. For instance, the amount of statin drug provided in polypill to reduce cholesterol may lower lipid profiles but has not been found to reduce mortality rates. When higher doses of are used, which do reduce mortality, the incidence of side effects rise, some of which can be mortal. in the combo pill may reduce the risk of strokes and heart attacks, but because two of the ingredients in the polypill reduce levels of coenzyme Q10 needed for heart muscle energy, it may also increase the risk of heart failure.

The authors claim that side effects would be minimal with polypill, even though most of the drugs included in the polypill deplete the body of essential nutrients. The thiazide water pill depletes the body of coenzyme Q10, magnesium and potassium, all essential nutrients required for maintenance of normal heart rhythm. It appears some of the ingredients in the polypill are needed just to counter side effects and deficiencies caused by the cure-all pill itself. For example, aspirin, one of the components of the polypill, depletes the body of folic acid.

Replacement for some nutrients depleted by the drugs in the polypill, such as coenzyme Q10, magnesium, potassium and vitamin C, are not even considered by its inventors. Magnesium is a natural calcium blocker and would eliminate the need for a synthetic drug. High-dose vitamin B6, not included in the polypill, could replace the need for a blood pressure drug (angiotensin II receptor antagonist).

The originators of the polypill included folic acid in their combo pill to reduce undesirably high levels of homocysteine, a protein that can build up in the blood circulation and is associated with strokes and blood vessel disease. Yet recent studies indicate vitamin B12 is also needed to effectively reduce homocysteine, a vitamin that was not included in the polypill, but is included in most multivitamins.

It is obvious that a well-designed multivitamin containing magnesium, potassium, coenzyme Q10, folic acid, vitamin B12, vitamin B6, vitamin C in ample amounts may equal or exceed the proposed benefits of the polypill and be more affordable in third-world countries where the polypill is suggested for use. Many heart attacks, in particular the sudden-death variety, are prompted by a shortage of magnesium, which is a heart muscle relaxant. The omission of magnesium from the polypill ingredients is a major oversight.

The addition of herbal ingredients such as Ginkgo biloba, green tea, ginger root and bioflavonoids may further enhance the cardioprotective properties of a multivitamin.


As a counterpoint, here a recent article in The Guardian. It seems that food may be more effective and have less side effects than a combination of pharmaceuticals...


How to live longer: a Polymeal a day

Sarah Boseley, health editor
Friday December 17, 2004
The Guardian

Never mind the tablets - heart disease could be cut by 76% and men could expect to live more than six years longer if they simply ate the right meal once a day, doctors said yesterday.

Last year the British Medical Journal ran a paper advocating the "Polypill" - combining aspirin, folic acid and cholesterol-lowering and blood-pressure drugs - for everybody over 55. But an article in the Christmas issue says a "Polymeal", containing fish, wine, dark chocolate, fruits and vegetables, garlic and almonds, would achieve roughly the same effect.

Men on the Polymeal would increase their life expectancy by 6.6 years and women by 4.8 years, say the authors, Oscar Franco and colleagues from the department of public health at Erasmus University in Rotterdam.

"The Polymeal promises to be an effective, non-pharmacological, safe and tasty alternative [to the Polypill] for reducing cardiovascular morbidity and increasing life expectancy in the general population," they write.

The doctors searched medical literature to find foods that have been proven to lower the risk of heart disease. Drinking 150ml of wine a day cuts the risk by 32%, they say, and fish consumed four times a week reduces it by 14%. A daily intake of 100g of dark chocolate and 400g of fruit and vegetables lower blood pressure, further cutting the risk of heart disease. Garlic and almonds both lower cholesterol levels. The daily Polymeal contains 2.7g of garlic and 68g of almonds.

"Combining all the ingredients of the Polymeal resulted in cardiovascular disease being reduced by 76%," they write. "Whether increasing the amount of each ingredient would increase the effect of the Polymeal is uncertain. On the other hand, decreasing the quantities could be expected to reduce the effects of the Polymeal."

Men would not only have a longer life expectancy, but also live nine years longer without heart disease, while women would be free of it for eight years longer.

The Polymeal has no serious side-effects, they say, in contrast to the Polypill. But they do note: "Fish consumed in larger amounts than recommended as part of the Polymeal has been related to raised blood mercury concentrations, especially with large fish such as shark and swordfish."

There are issues around garlic, but not in the long term. "Adverse effects reported for garlic include malodorous breath and body odour. As garlic is destined for mass treatment, few people will still notice this after a while," they say.

However, they add: "We do not recommend taking the Polymeal before a romantic rendezvous, unless the partner also complies with the Polymeal."

The Polymeal can either be eaten as an entire meal - a recipe by the chef Raymond Blanc suggests watercress soup, grilled fillet of mackerel with a tagine of winter root vegetables, chickpeas, toasted almonds and roasted garlic, followed by chocolate mousse - or the ingredients can be eaten separately during the day, say the doctors.

They warn that the Polymeal should not be taken with excess alcohol, to avoid compromising the health benefits and "in order to avoid intoxication and conflicts with friends, relatives and authorities".


An online version of the BMJ original :

The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%


September 2006: Polypill raises its head again
3-in-1 heart pill could save millions
The polypill would work by reducing future crippling events such as heart attacks and strokes. The World Heart Federation is currently working to promote this initiative, and believes that a pill could be ready in the next year or two.

What ever happened to proper nutrition and a healthy lifestyle as primary prevention?

Perhaps they aren't profitable enough...


For real prevention, look at the nutrients...

Magnesium Reduces Sudden Cardiac Death Risk in Women
Researchers at Harvard Medical School followed 88,375 women for 26 years, evaluating their magnesium intake, blood levels of magnesium, and the number of sudden cardiac deaths (heart attacks often caused by arrhythmia). Women with blood levels of magnesium in the highest quartile had a 77% reduced risk of sudden cardiac death.

There is no drug or combination of drugs that can claim a similar rate of reduced mortality for a sudden cardiac arrest. Since magnesium is low in many diets and is used up by stress it is one of the most important nutrients in a basic supplement support program.

 


posted by Sepp Hasslberger on Monday June 30 2003
updated on Friday December 3 2010

URL of this article:
http://www.newmediaexplorer.org/sepp/2003/06/30/polypill_miracle_cure_or_insanity.htm

 


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Readers' Comments


i'm interested in conducting an extensive research on polypill.but, i would like to ask a few questions and hopefully the author can gain more details information from scientists responsibled.
the questions are as followed:
1.how to combine so many compounds into a single pill?

2.what will it cause and the reaction from the combination?

3.it is claimed that polypill is a 'blunderbuss medicine' and some questioned about the spectacular claim on reduction of disease by statins.

i am looking forward to the feedback from you..hope that you will cooperate and help me in doing my research project..thank you very much..

Posted by: yusrina on November 30, 2003 05:44 PM

 


This is a reply to the previous comment by yusrina, and another exchange that followed, always in relation to the poly-pill proposal:

Josef Hasslberger first reply:

thank you for your comment.

I suppose that the questions you ask can only be answered definitely if someone should actually make the pill and start feeding it to volunteers, observing the side effects and the good effects, as they occur. No shortcuts there. We can say it works or it doesn't, but in the absence of actual experimentation, it's mostly speculation.

Unfortunately I can do nothing to arrange for such experimentation.


Second comment by yusrina (dihah jamaludin):

first and foremost, thanks a lot for your reply to my comment...actually, what i know about polypill is that the pill is proposed by a British scientist, Sir Nicholas Wald...he claim that polypill is effective in reducing the risk of heart attacks and strokes...however, other scientists still question the validity of the analyses and condemned the proposal as irresponsible...president of the American Heart Association (AHA), Robert O.Bonow claims that treatment with medications and lifestyle changes should be done as polypill will be used without medical examination/blood tests...i wonder how he proposed this 'miracle polypill' or the historical perspective of polypill...i believe that this polypill is only alternative way to prevent or reduce...the most important one is one's diet modification...i'm glad to hear your comment...thanks.


Josef Hasslberger reply of 1 December 2003:

my view is that the illnesses the poly pill is supposed to help prevent can more easily and more effectively be prevented by lifestyle changes and by changes in nutritional habits. Our bodies are wonderful self-healing machines, and they WILL self-heal, if we give them the right conditions and the right fuel. All we need to do is make the information available to people in an easily understood way, supply all the needed nutrients in sufficiently high doses (especially vitamin C, which the human body is unable to synthesize) and illness will largely be overcome.

Pharmaceutical intervention, such as with cholesterol lowering drugs or aspirin, is always based on interference with body biochemistry, rather than with bringing the biochemical pathways back to normal by supplying the right nutrients.

Pharmaceutical intervention that combines several such "interfering" drugs can - in my humble opinion - only lead to disaster.

I have also made two further articles about the poly-pill proposal, which you may want to read as well:

1) "Polypill" insanity again and

2) A Polypill of nutrients?

Posted by: Josef Hasslberger on December 1, 2003 12:56 PM

 


Here another comment received from dihah jamaludin (yusrina):

well, a bunch of thanks to you..i found that the articles that you've just sent to me are beneficial and related to my research topic..i just forgot to ask you something..while i was reading my materials..i found that polypill could offer longevity for extra 11or 12 years without having a heart attack or stroke..what do you think about that statement given by Sir Nicholas?and one more thing..some of the people..i think medical experts..they had a spectacular claim on reduction by statins..actually, what is the claim and i hope that you can give me a short answer for that question..anyway,i'm happy to receive e-mails from you and hope that you can help me to continue my research until the end..

yours truly, dihah jamaludin.


My reply, sent on 3 December 2003:

regarding the claim of an extra 11 or 12 years of heart-attack-free life, Dr. Mercola comments on this in his excellent article available on Dr. Mercola's site - here -

You may also be interested to know that the general question of effectiveness of statin drugs (one of the proposed ingredients in the hypothetical polypill) in lowering the incidence of heart attacks is in grave doubt. It appears that these medications may lower cholesterol, which is thought to be a marker, but that they leave the heart attack statistics pretty much untouched.

There are natural substances with a better track record in preventing heart attacks than the statins. One of them is vitamin C, as proposed by Dr. Rath. A recent article on my site points you to this data.

Posted by: Josef Hasslberger on December 3, 2003 12:44 PM

 


We have seen the news in our local news paper in India that issued in your country on dtd 05.10.08.

We are interested to buy this poly pill as earliest so we are required the price.

Regards,

Posted by: Sheikh S Ahmed on November 28, 2008 10:00 AM

 


I believe you would be better off finding out what the basic nutrients are our bodies need to stay healthy, and adjust foods accordingly. People who eat right and have a reasonable amount activity (like walking and light sports) have a very low incidence of heart trouble.

Posted by: Sepp on December 1, 2008 06:31 AM

 















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