Health Supreme by Sepp Hasslberger

Networking For A Better Future - News and perspectives you may not find in the media

Networking For A Better Future - News and perspectives you may not find in the media

Health Supreme

News Blog

Site Map





Food for Thought


Human Potential






The Media

War Crimes


Articles Archive


See also:


Communication Agents:

INACTIVE  Ivan Ingrilli
  Chris Gupta
  Tom Atlee
INACTIVE  Emma Holister
  Rinaldo Lampis
  Steve Bosserman
  CA Journal


Robin Good's
Web sites:












The Individual - Human Ability:


Society - Politics:






August 14, 2007

Statin Drugs Cause Amnesia, Behavioral Disorders and Cognitive Loss

Duane Graveline, a former astronaut and medical doctor is one of the few 'lone voices' warning of the side effects of statin drug use. His website probably has more information on statin drug side effects than any other place on the internet.


Duane 'Spacedoc' Graveline, author of Statin Drugs Side Effects: the misguided war on cholesterol

Doc Graveline has now released some more of his research into the side effects of cholesterol lowering drugs. These medicines, which are the biggest sellers in the history of our human pharmaceutical experiment, interfere with the body's ability to produce cholesterol in the liver, and not only that. By suppressing a vital metabolic pathway, they interfere in cholesterol production but also in the synthesis of Coenzyme Q 10 as well as in the synthesis of dolichols, selenoproteins and other important substances.

We have been told for years that cholesterol is bad, or alternatively that there is good cholesterol and bad cholesterol, but always the message has been that we need to avoid cholesterol like the plague. We must do everything to lower this indictor of trouble. Unfortunately that is very misleading, because cholesterol is a vital substance our bodies need to function properly, and rather than the cause of heart trouble it is merely an indicator that something else is wrong and that the body needs more cholesterol to detox.

The side effects that come with our interfering in an important metabolic pathway are grave and at times extremely painful. Muscle pains are reported by large numbers of users. You only need to read the comments readers of this site have posted at the end of this article about LIPITOR, one of the cholesterol lowering statin drugs. The dissolution of muscle tissue is not only painful, it can lead to kidney overload and eventual death by rhabdomyolysis. But another class of side effects that comes with the use of statin drugs are cognitive degeneration, amnesia and uncharacteristic behavior, such as aggressive or destructive reactions that need little or no external provocation.

Why are those drugs still on the market after years of documented side effects?

They are big business for the pharmaceutical companies that make them, blockbusters that bring in literally billions of dollars every year. No matter the suffering they bring - or the perfectly useless nature of 'cholesterol goals' doctors are told to push their patients to reach.

The important question seems to be to me whether good business for the pharmaceutical industry is really worth the destruction of our health and the suffering and degradation of our quality of life inflicted by these drugs.

- - -

Here are three short papers by Doc Duane Graveline on mental and cognitive "side"-effects of statin drugs.


Although the attacks of transient global amnesia that I experienced from my introduction to statin drugs were unforgettable and much more responsive to media attention, the more pervasive effect of statins on the entire memory process is far more important to me in my challenge to inform both doctors and patients about statin drug cognitive damage. No one has said it better than Muldoon and no one is better qualified to say it than Muldoon – “there is demonstrable cognitive loss in 100% of statin users”.

Twice Muldoon has demonstrated this effect and twice he has published in the medical literature and yet we still have practicing physicians who are completely ignorant of this part of statin’s legacy. The reason, unfortunately, is largely because our physicians are far too busy to read the medical literature and far too often tend to get their information about statins from the persuasive drug “reps”. Our drug companies have much to gain by telling busy doctors only what they want them to know. That is the job of the “reps”. I doubt there is one rep in the thousands out there who has ever related concern about statin associated cognitive loss to the doctor. The numbers of transient global amnesia attacks associated with statin drug use, the compelling research results of men like Muldoon and the legions of our elderly in assisted living and nursing homes who are transformed almost immediately into progressive dementia patients by their statins are things better left unsaid by our drug “reps”.

Does the drug company know of this? Have they been keeping up with the adverse drug reports? Of course the drug companies know of this particular side effect of statins. It was first brought out 12 years ago during the clinical evaluation phase of Lipitor. This is the first time Lipitor was used on humans. 2,503 volunteers participated in this part of Lipitor testing. Of this number, seven experienced transient global amnesia attacks on Lipitor and four more reported severe memory impairment for a total of 11 cases of cognitive impairment out of 2503 subjects, or a case rate of about 5/1,000. Not one word of this was ever transmitted to the public. Think of the marketing effect of admitting that out of every 1,000 people taking this drug, five could expect severe cognitive effects. Think of the impact on CEOs, presidents, pilots, heavy equipment operators and school bus drivers. This is why, when I first reported this to FAA in 2000, they were allowing commercial airline pilots to fly on statins because, “They did not know statins could do that.” And at the Pentagon where fighter pilots were allowed to fly with statins, the flight surgeons there, “did not know that statins could do that.” Yes, management knows and management has been attempting to keep this information hidden as long as it can because untold billions of dollars are at stake.

The "Why" of statin drug cognitive damage had to await Frank Pfrieger's research results first released in 2003. Pfrieger found that cholesterol was vital to synaptic function in the brain and was produced by our glial cells for this purpose. Ordinary blood cholesterol is not available to the brain because when combined with lipoprotein, the resulting molecule is too large to pass our blood brain barrier, so we have evolved this glial cell mechanism to support synaptic function. Glial cells are just as susceptible to statins as any other cell in our body and we finally had an explanation for why Muldoon was right. In the absence of sufficient cholesterol, cognitive functions must suffer. One hundred per cent of statin users have demonstrable cognitive loss!

The reason many of us are not aware of this is because we are not precise creatures. Although our computers are precise, we humans forget. It is part of our inherent makeup. We can lose 10% of our capacity and never bat an eye, lost in the background of daily “forgets”, the best we can do.

Duane Graveline MD MPH

- - -


“My husband was prescribed Vytorin 3 months ago and has been experiencing severe side-effects from it. Within a month of taking this drug, his personality began changing. He has become easily agitated, and he is growing more and more hostile and aggressive when upset. Frankly, I don't like the person he has become. He is paranoid, unable to focus clearly, has no sexual interest and does not remember many things that I have told him. After reading the content on your website and several others, I am convinced that Vytorin is toxic to his system.”

This is now a very common story in my repository of statin drug side effects from victims all over the world. From aggression, irritability, hostility, paranoia, homicidal ideation, road rage-like behavior, depression and suicidal ideation, all share one thread – that of neuropeptide synthesis, the magic peptide strand that makes us what we are and governs of every action. Imagine, every thought, every sensation and every emotion you have ever experienced governed by the makeup of proteins and sugars on a growing peptide strand.

Deep in the cells of all of us are tiny factories responsible for this function. Henry Ford has come to the ER (endoplasmic reticulum), for that is what this micro-assembly line resembles. Within these tubules are deposited protein after protein, the type and placement of each protein made supercritical by the insertion, here and there, of a certain kind of sugar that will tell the growing protein strand just where to fold and in what direction. The protein strand has become a glycoprotein strand with a far more complex range of possibilities as to how the final molecule looks – and structure determines function. A twist here or right angle there makes all the difference between anger and blind, berserker anger or love and passionate love.

From the ER the completed peptide strand now called a neuropeptide, passes into the so-called Golgi apparatus (named after an Italian scientist) where it is packaged into a vesicle and carried down the nerves to storage centers near the synapses until needed.

Now comes our statin drug a.k.a. reductase inhibitor to do its number on the reductase step of our vital mevalonate pathway. Unfortunately, interference at this point inhibits not only cholesterol but also CoQ10, dolichols, selenoproteins and other important functions using the same pathway. It is the dolichols that are involved in the neuropeptide assembly. Imagine what would happen if we suddenly had only one-half of our normal dolichol supply? This is almost certainly the mechanism for the behavioral side effects of statins.

Our entire process of neuropeptide formation, our ER assembly line, is orchestrated by dolichols. Suddenly this entire system becomes disturbed and most of our doctors have not the slightest idea of this potential for statin effect, and this is not just some one in a million sensitivity reaction, this tendency is inevitable with statin use. And the severity of symptoms can vary from just barely detectable to homicides and suicides.

CoQ10 deficiency associated with statin use is beginning to be understood by doctors in our country but statins and personality change is a complete mystery and usually it is “off to the psychiatrist”, who doesn’t understand it a bit better!

Duane Graveline MD MPH

- - -


A review of Medwatch data from the period of 11/03/97 to 4/27/07 reveals 408 case reports of amnesia associated with Lipitor use. Prior to this time Wagstaff and others had reviewed available Medwatch data from November 1997 to September 2002. They gleaned 60 cases of transient global amnesia associated with the use of Lipitor, Zocor and Pravachol and reported their findings in Pharmacotherapy in August of 2003. Pravachol contributed only one case to this total, the remaining cases were equally divided between Lipitor and Zocor.

Subtracting Wagstaff’s 60 cases from the 408 obtained from my recent Medwatch review gives 348 new cases of Lipitor associated amnesia reported to Medwatch since September 2002. A very rough estimate of total statin associated amnesia cases could be obtained by doubling this figure, based upon Wagstaff’s original data about Zocor and additional cases from other statins (Mevacor, Lescol, Crestor, Pravachol and Vytorin aka Zocor). So 700 would be a very conservative estimate of all statin associated amnesia reports at this time.

When one takes into consideration the well-known fact that only a small percentage of adverse side effects are reported to Medwatch, this already considerable figure could reach a truly impressive level if it contained all cases. Many researchers feel that fewer than 1% of statin side effects are reported. Others feel to figure is closer to 10%. At 1% our 700 become 70,000 and at 10% our 700 becomes 7,000 – either figure entirely adequate to get some sort of response from FDA. We are not talking urinary retention or anxiety here, we are talking amnesia, eradication, more or less, of your mind. Shouldn’t this get greater consideration in our society, like a black box warning so that doctors will understand what we are dealing with? Or is there some other factor here, related to the fact that since 2004, the drug companies are paying for their own drug safety monitoring. This is Medwatch, our government’s protective umbrella, supposedly shielding us from adverse post-marketing drug events, but actually completely subservient to the drug companies in that money for Medwatch salaries comes from drug company pockets.

And to think about how little of this information is known to the practicing physicians. Not a day goes by that I do not get a report or two from doctors saying, “I didn’t know statins could do that.” And this is seven years after my own experience with Lipitor associated amnesia. “Statins don’t do that” was a refrain I heard over and over again from both doctors and pharmacists as I sought answers to my two statin associated amnesias. During the first episode at 10 mg daily, I retrograded back ten years and, for six hours, knew neither my new wife nor my new home. In my second case at 5 mg daily, I was 13 years of age for 12 terrifying hours and laughed hysterically when they told me I was married with children and a family doctor. I was 13!

A few months ago I attended a shipboard medical seminar where the fully credentialed cardiologist who was giving the credit course told me he had never seen a case of memory problems or amnesia in someone on a statin drug. He was amazed and completely unreceptive when I gave him a few statistics. And what about huge clinical studies wherein thousands of participants are placed on today’s heroic doses of statins with nary a problem according to the investigators. Pfizer’s own statistics tell us to expect five cases of amnesia for every one thousand statin users. Who is doing the monitoring of these studies for side effects? What questions are being asked? If neither doctor nor patient knows that memory lapses are possible in a statin user how often will it be reported? I can only surmise that cognitive side effects from statin drug use are not being seen because they are not being looked for.

Duane Graveline MD MPH

For more information on statin drug side effects see Duane Graveline's

See also:

Cholesterol metabolism links early- and late-onset Alzheimer's disease
In fact, the brain needs a high level of cholesterol, according to Bu. "The brain represents only about 2 percent of your body weight, but actually has about 20 percent of your body's cholesterol," Bu says. "There is strong evidence that cholesterol is important for synaptic function and is an essential component of cell membranes in the brain, and I believe partial defects in the regulation of cholesterol metabolism in the brain likely contribute to the development of Alzheimer's."

Past research by others implies that neural synapses, the junctions that nerves use to send impulses and communicate, are particularly sensitive to cholesterol levels and that interfering with cholesterol transport and metabolism could cause loss of synapses and degeneration of nerves.

If "interfering with cholesterol transport and metabolism" is detrimental to brain function and can cause loss of synapses and degeneration of nerves, perhaps taking statin drugs, whose only function is to interfere with the liver's endogenous production of cholesterol, is not such a good idea...

First comprehensive paper on statins' adverse effects released
"Muscle problems are the best known of statin drugs' adverse side effects," said Golomb. "But cognitive problems and peripheral neuropathy, or pain or numbness in the extremities like fingers and toes, are also widely reported." A spectrum of other problems, ranging from blood glucose elevations to tendon problems, can also occur as side effects from statins.


posted by Sepp Hasslberger on Tuesday August 14 2007
updated on Thursday November 25 2010

URL of this article:


Related Articles

Statin Drugs Cause Amnesia, Behavioral Disorders and Cognitive Loss
Duane Graveline, a former astronaut and medical doctor is one of the few 'lone voices' warning of the side effects of statin drug use. His website probably has more information on statin drug side effects than any other place on the internet. Duane 'Spacedoc' Graveline, author of Statin Drugs Side Effects: the misguided war on cholesterol Doc Graveline has now released some more of his research into the side... [read more]
August 14, 2007 - Sepp Hasslberger

Lipitor Neurological Side Effect: Amyotrophic Lateral Sclerosis, Alzheimer's
Lipitor and other statin drugs are well known for their degradation of muscle tissues and the sometimes excruciating pain that comes with this. What is less well known is that the progression of this muscle wasting side effect may lead to a diagnosis of amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease or motor neurone disease, described as a chronic, progressive, almost invariably fatal neurological disease. Duane 'Spacedoc' Graveline,... [read more]
October 07, 2006 - Sepp Hasslberger

Lipitor, Zocor, Pravachol: Cholesterol Lowering Drugs Cause Cancer?
Lipitor has been known to cause very painful and potentially fatal muscle wasting also known as rhabdomyolysis as detailed and confirmed by numerous personal comments on two previous articles on this site: Lipitor - The Human Cost and Lipitor: Side Effects And Natural Remedy. This side effect is apparently so widespread that the use of painkillers has skyrocketed in the wake of increased statin drug use. Recently Crestor, another similar... [read more]
January 14, 2005 - Sepp Hasslberger

Big Pharma's Cholesterol Roulette - Statins and Glyconutrients
Statin drugs are some of the most damaging medicines ever invented, but the situation is especially grave because statins - they go under names such as Lipitor, Mevacor, Pravachol, Crestor and Zocor - are officially recommended by the highest health authorities as a "preventive" measure for heart attacks. The Cholesterol Molecule - Image credit: World of Molecules. These drugs are highly inefficient in what they are advertised to do. As... [read more]
May 15, 2007 - Sepp Hasslberger

Cholesterol Scam Exposed - Throw Away Your Statins!
Readers of this site have known it for some years, but the news is coming out more and more clearly: Cholesterol is a scam perpetrated by pharmaceutical interests at the cost of the health of millions of believers in modern medicine. Not only do cholesterol lowering medications - the so-called statin drugs - have appalling side effects, they are practically useless, while having been the greatest money makers for pharmaceutical... [read more]
January 24, 2007 - Sepp Hasslberger

Forget Cholesterol - it's really not relevant
For decades we have been told that we must avoid cholesterol at any cost if we want to stay healthy. Want to protect your heart and arteries? Then forget cholesterol, it is almost certainly one of the great myths of 20th century medicine. As a matter of fact, there seem to be certain benefits to high cholesterol that medical authority is very reluctant to tell us about. In his article... [read more]
June 03, 2003 - Sepp Hasslberger




Readers' Comments

Action: Statin Drug Investigation Proposed - Sign Petition Much evidence suggests that a low serum cholesterol is associated with depression, suicide, muscle damage, memory loss and general ill-health. As the signature count begins to climb, we can see the impact of having patients telling of their own bad experiences with statins. It has been the case for far too long now that the medical profession, as a whole, has not seen the obvious nor has it listened very well to what the patients on statins have been telling it.

Posted by: Sepp on December 12, 2007 04:25 AM


I have been taking statin drugs for several years. Over the past 18 months I have been suffering memory loss episodes. Mostly they last 5-10 minutes and I don't know where I am or what the date is. I also usually cannot remember where my 3 grown up children are now living. I often complain of being afraid. While these episodes occur I cannot make new memories and frequently repeat the same questions to those around me. I have had tests for TIA and epilepsy which have been inconclusive and my doctor is at a loss to explain my problem. Duane Graveline describes my condition precisely. Any ideas?

Posted by: Kevin Griffith on February 8, 2008 11:46 PM



I suggest that you might want to check out these two articles,

Lipitor - The Human Cost

Lipitor: Side Effects And Natural Remedy

especially the stories on various side effects many readers added in their comments.

Then ask your doctor, whether you should continue taking the drug. You might also tell him of reports on a recent trial as detailed in this article:

What's cholesterol got to do with it?

But in the end, the decision of what you want to do with your body is yours. Inform yourself and then make your decision.

Posted by: Sepp on February 9, 2008 11:09 AM


Security code:

Please enter the security code displayed on the above grid

Due to our anti-spamming policy the comments you are posting will show up online within few hours from the posting time.



The Individual Is Supreme And Finds Its Way Through Intuition


Creative Commons License
This work is licensed under a Creative Commons License.

These articles are brought to you strictly for educational and informational purposes. Be sure to consult your health practitioner of choice before utilizing any of the information to cure or mitigate disease. Any copyrighted material cited is used strictly in a non commercial way and in accordance with the "fair use" doctrine.



Enter your Email

Powered by FeedBlitz



Most Popular Articles
Lipitor: Side Effects And Natural Remedy

Lipitor - The Human Cost

Fluoride Accumulates in Pineal Gland

Original blueprints for 200 mpg carburetor found in England

Medical system is leading cause of death and injury in US

Aspartame and Multiple Sclerosis - Neurosurgeon's Warning

'Bird Flu', SARS - Biowarfare or a Pandemic of Propaganda?



More recent articles
Chromotherapy in Cancer

Inclined Bed Therapy: Tilt your bed for healthful sleep

European Food Safety Authority cherry picks evidence - finds Aspartame completely safe

Did Aspartame kill Cory Terry?

Retroviral particles in human immune defenses - is AIDS orthodoxy dead wrong?

Vaccine damage in Great Britain: The consequences of Dr Wakefield’s trials

Archive of all articles on this site



Most recent comments
Uganda: Pfizer Sponsored AIDS Institute Snubs Natural Treatment Options

Lipitor: Side Effects And Natural Remedy

AIDS: 'No Gold Standard' For HIV Testing

Lipitor: Side Effects And Natural Remedy

'Global Business Coalition' Wants More Testing: But Tests Do Not Show AIDS



Candida International

What Does MHRA Stand For??

Bono and Bush Party without Koch: AIDS Industry Makes a Mockery of Medical Science

Profit as Usual and to Hell with the Risks: Media Urge that Young Girls Receive Mandatory Cervical Cancer Vaccine


Share The Wealth

Artificial Water Fluoridation: Off To A Poor Start / Fluoride Injures The Newborn

Drinking Water Fluoridation is Genotoxic & Teratogenic

Democracy At Work? - PPM On Fluoride

"Evidence Be Damned...Patient Outcome Is Irrelevant" - From Helke

Why Remove Fluoride From Phosphate Rock To Make Fertilizer


Evolving Collective Intelligence

Let Us Please Frame Collective Intelligence As Big As It Is

Reflections on the evolution of choice and collective intelligence

Whole System Learning and Evolution -- and the New Journalism

Gathering storms of unwanted change

Protect Sources or Not? - More Complex than It Seems



Islanda, quando il popolo sconfigge l'economia globale.

Il Giorno Fuori dal Tempo, Il significato energetico del 25 luglio

Rinaldo Lampis: L'uso Cosciente delle Energie

Attivazione nei Colli Euganei (PD) della Piramide di Luce

Contatti con gli Abitanti Invisibili della Natura


Diary of a Knowledge Broker

Giving It Away, Making Money

Greenhouses That Change the World

Cycles of Communication and Collaboration

What Is an "Integrated Solution"?

Thoughts about Value-Add




Best sellers from