Health Supreme by Sepp Hasslberger

Networking For A Better Future - News and perspectives you may not find in the media

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November 05, 2004

AZT, Nevirapine - Children In New York Orphanage Given Toxic Drugs

A Catholic orphanage in New York - Incarnation’s Children Center - has allowed its charges, mostly orphans and children removed from their mothers' care, to be used in cruel experiments with drugs that are known to kill most of the patients taking them. This tragedy has taken place under our very noses - we weren't looking.

Journalist Liam Scheff has written about this scandal before and you can see that previous article here. Now, Crux Magazine has taken up the story with another instalment from Scheff. The matter is all the more serious, when we find out that toxic drugs have not always been the treatment of choice. The Children's center, in their own published history, relates that early on in the epidemic, when AZT and other toxic drugs were not yet available, children did well and actually got better with good nutrition and care:

"Early in the epidemic, HIV disease of childhood was considered to be a down-hill course leading to death. But in the late 1980's, before AZT was available, many very ill children admitted to ICC got dramatically better with proper nurturing and high-quality medical and nursing care."

So let us not forget, immunity is a function of a healthy body, and sufficient nutrients are essential to maintain that function. Something our pharma-oriented medical machine seems to have completely forgotten. Wonder Why...

HIV Negative - "Noble Doctors Try New Drugs on AIDS Orphans"

by Liam Scheff
Crux Magazine. November, 2004.

In June, 2003, I got a call to investigate a place called Incarnation’s Children Center (ICC), a Catholic orphanage for HIV-positive children in New York City. I was told that terrible things were happening there.

ICC is a home for children who test HIV-positive. Some of the children are orphans; their parents use drugs and can’t care for them. Some of the children have parents and families, but the parents have trouble enforcing the heavy AIDS drug regimen. When that happens, the city agencies bring the children into ICC, where their drug regimens are carried out without fail.

Their press page describes ICC as an "Ellis Island . . . envisioned as a sanctuary of love, a home-like nurturing residence where HIV-positive children would receive the best possible nursing and medical care while awaiting placement into foster homes."

That didn’t sound so terrible.

ICC was also receiving federal funds for running drug trials with the children. "In 1992, an outpatient clinic for HIV-positive children was established; the same year, with funding from the National Institute of Allergy and Infectious Diseases [a subdivision of the NIH], the clinic became a sub unit of the Columbia University Pediatric AIDS Clinical Trials Unit." In 1996, "under the direction of Dr. Stephen Nicholas, thirty-four children [were] participating in seven clinical trials . . . ."

Dr. Nicholas was listed among "The Best Doctors in New York in New York Magazine and in the 1996-97 edition of The Best Doctors in America." ICC received government trial-funding through 2002. Dr. Nicholas has since moved to Harlem Hospital. ICC’s new medical director is Katherine Painter. She told me that children at ICC are now enrolled in clinical trials at one of a dozen area hospitals that work in conjunction with ICC. "Children participating in a drug trial undergo monitoring, testing, and supply of an experimental drug through their outpatient clinic, and we maintain that treatment here," she said.

If I wrote for the New York Times, I would have had my story: "Noble Doctors Try New Drugs on AIDS Orphans."

On the surface, it sounds innocuous and slightly tragic, but also heroic and perhaps hopeful. New drugs—that can’t be a bad thing, can it? AIDS orphans. Well, if anyone deserves a new drug, it’s AIDS orphans, right?

But I had doubts and lingering questions. What exactly are the "new drugs?" Do they have any effects that are deleterious? The ICC webpage listed them. It turned out that the drugs weren’t really new at all—they were old—nearly 40 years old. The primary drug used in trials at Incarnation Children’s Center is called AZT. It was developed in 1964. So, not a new drug. Does that matter? No, if the drug helps the kids. But there was a problem.

AZT isn’t a very helpful drug—unless, I suppose, you enjoy funerals. AZT has a very special use. It’s a chemotherapy drug used to kill the cells that make up living tissue and blood. It was designed in a cancer research lab in 1964 as a potent cell-killing agent called a nucleoside analogue. It works by disrupting cellular replication at the genetic level.

Our DNA is made up of four bases that combine in pairs. These line up, spiraling into a double helix. DNA codes for all our proteins; it’s a blueprint for our building blocks. AZT stops the spiral; it breaks the chain and kills the cell. Not so innocuous, after all.

AZT never got out of the lab. It was far too effective at killing cells even for short-term use. It was shelved, and no patent was filed.

In 1986, Burroughs Wellcome (now GlaxoSmithKline) was interested in entering the AIDS drug market. Recycling an old drug was cheaper than designing a new one. So AZT was brought out of storage. Test labs that ordered the drug for experimentation received it in a package bearing a skull and crossbones on a bright orange background. The label read "TOXIC. Toxic by inhalation in contact with skin and if swallowed. Target organ(s): Blood bone marrow. If you feel unwell, seek medical advice (show the label where possible). Wear suitable protective clothing."

Today, Glaxo sells AZT under the brand name "Retrovir" and as an ingredient in "Combivir" and "Trizivir." But the warning label tells the same story: "Retrovir [AZT] has been associated with Hematologic Toxicity [blood toxicity], including Neutropenia [loss of neurophils, an essential component of blood] and Severe Anemia [potentially fatal lack of blood production] . . . . Prolonged use of Retrovir has been associated with Symptomatic Myopathy [muscle wasting]."

"LacticAcidosis and Severe Hepatomegaly [liver swelling] with Steatosis [fat degeneration], including Fatal Cases, have been reported with the use of Nucleoside Analogues [AZT, 3TC, ddl, D4T] alone or in combination, including Retrovir and other Antiretrovirals (see warnings)."

The most surprising thing about AZT is that it doesn’t even claim to work: "Retrovir is not a cure for HIV infection . . . The long-term effects of Retrovir are unknown at this time . . . The long-term consequences of in utero and infant exposure to Retrovir are unknown, including the possible risk of cancer."

This wasn’t so wonderful for the kids at ICC. But it was good for Glaxo. They make a lot of money with their AIDS drugs. Drugs containing AZT as an ingredient account for about one billion British pounds (over 1. 5 billion dollars) in Glaxo’s 2002 sales alone. Other nucleoside analogues provide another 470 million pounds (750 million dollars) in sales.

We know that something doesn’t have to be good for you to be profitable. Think of cigarettes or alcohol or fast-food. But it’s medication we’re talking about, not French fries. You’d think that a drug with such terrible toxicities would simply never get approved for use by the US Food and Drug Administration (FDA).

Unless, of course, the FDA approval process was easily corrupted. For example, a bad drug might get approval if a trial were heavily influenced, and even overseen, by the very pharmaceutical companies that produced the drug. That would mean that pharmaceutical reps, with a vested interest in getting the drug to market, would oversee and direct the recording process during the drug trial—or perhaps that CEOs of drug companies would go work at the FDA for a stint, approving drugs, then turn around and get back into the company.

Or perhaps doctors would be given favors—I don’t know, expensive trips, monetary rewards, that sort of thing—to be loyal to a particular product, or to review it favorably. Or that doctors fell victim to peer pressure from inside their academic community to support an ongoing paradigm, and not to rat out a bad public health policy.

But even suggesting that sort of thing is ridiculous, isn’t it? I mean, there’s no corruption in pharmaceutical-driven medicine. Is there?

Here’s a hint.

In 2000, Dr. Marcia Angell, editor of the New England Journal of Medicine (NEJM), resigned from the journal. In her parting May 2000 editorial, "Is Academic Medicine for Sale?" Angell wrote, "[Y]oung physicians learn that for every problem, there is a pill (and a drug company representative to explain it). [Physicians] become accustomed to receiving gifts and favors from an industry that uses these courtesies to influence their continuing education . . ." She added, "[T]he costs of the industry-sponsored trips, meals, gifts, conferences, and symposiums and the honorariums, consulting fees, and research grants are simply added to the prices of drugs and devices."

Angell asked, "What is the justification for this large-scale breaching of the boundaries between academic medicine and for-profit industry?"

ABC News reported that in 2000 pharmaceutical companies sponsored over 314,000 promotional events for doctors—from lunches to travel weekends—at a cost of nearly 2 billion dollars.

In 2002, the new editor of the NEJM, Dr. Jeffrey Drazen, officially dropped the journal’s 190-year restriction against medical authors accepting money from drug companies. The journal’s editors claimed that there simply weren’t enough doctors who didn’t have ties to drug company money. The new policy allows review authors to accept up to 10,000 dollars a year from each drug company for "speaking and consulting fees"—with no limit on total earnings. By contrast, there are no financial restrictions placed on the researchers running the studies, who often work directly for the company whose drug is being tested.

Does money influence drug studies? ABC News reported that in a survey of independently-run drug studies, drugs were found to be safe and effective about 50% of the time. But when a drug company sponsored their own trial, the positive rating nearly doubled to 90%.

Even without evidence of corruption, FDA approval does not ensure drug safety. According to the US General Accounting Office, 51.5% of drugs approved by the FDA from 1976 to 1985 had "serious post-approval risks," including "heart failure, myocardial infarction, anaphylaxis, respiratory depression and arrest, seizures, kidney and liver failure, severe blood disorders, birth defects and fetal toxicity, and blindness."

In 1986, AZT was rushed through its FDA approval trials in record speed. Overseen and funded by Burroughs Wellcome, the trials were marred by false reporting and a total breakdown of study controls. Nevertheless, the drug was released to the market.

Subsequent independent AZT studies revealed the obvious—the drug was deadly. In English, Australian, and Dutch studies, patients on AZT developed severe anemia, requiring multiple blood transfusions just to stay alive. In the Dutch study, three-quarters of the patients on AZT died.

Well, AZT wasn’t the only drug being used at ICC. The other was Nevirapine, which is marketed under the brand name "Viramune." And that drug . . . maybe we shouldn’t talk about that drug. Oh…might as well.

Nevirapine functions similarly to AZT. It interferes with the essential movement of genetic information in the cell. It blocks an enzyme which translates RNA into DNA.

There was a short period in research biology where it was imagined that this enzyme, called Reverse Transcriptase, only functioned in service to a particular kind of potential virus. This was quickly proven false. The enzyme didn’t belong to any particular virus or molecule. It was a part of normal, healthy cells—essential to our functioning. And Nevirapine blocks it.

Is that a bad thing? It is for people who’ve taken it whose skin has come off of their bodies. Right, well, I didn’t quite believe it myself, until I saw the European study of Nevirapine. Hands, abdomens, faces, and mouths, bursting with blood, flesh coming off like old paint steamed off a wall. The condition is called Stevens-Johnson Syndrome. Of course, those patients could have saved themselves the pain and just read the drug label (if they’d only been shown it). Here’s what it says:

“Severe, life-threatening skin reactions, including fatal cases, have occurred in patients treated with Viramune [Nevirapine]. These have included cases of Stevens-Johnson syndrome, toxic epidermal necrolysis, and hypersensitivity reactions characterized by rash, constitutional findings, and organ dysfunction. Patients developing signs or symptoms of severe skin reactions or hypersensitivity reactions must discontinue Viramune as soon as possible.”

It also warns of liver failure/toxicity. It seems that the drug can toxify the liver to such a great extent that it, well, dies: "Severe, life-threatening and in some cases fatal hepatoxicity [liver damage], including hepatic necrosis [liver death] and hepatic failure, has been reported in patients treated with Viramune."

The other drugs used in the children’s regimen are called protease inhibitors. They have warning labels of their own, and they’re pretty painful too. Not much better, maybe worse. Doesn’t seem like much of a favor to these orphans. But these drugs—AZT and Nevirapine, protease inhibitors—aren’t just used on orphans in NYC. These are the main AIDS drugs used on people who doctors consider at risk for AIDS all over the world.

There’s been time to measure the effect of AZT. It has been given to hundreds of thousands of gay men in the US who tested HIV-positive, whether they were sick or not. United States AIDS deaths increased by thousands annually after the mass-introduction of AZT in 1987, from 11,000 in 1986 to nearly 50,000 in 1994—the height of AZT use. Sharp criticism of AZT began appearing in the press. Patients and physicians complained openly of the drug’s effects and cut doses or discontinued it altogether. The death rate declined—substantially—and before the introduction of protease inhibitors, which the industry likes to credit for the decline. Was it a coincidence? I don’t know. You can’t ask dead people what they died of. I do think it’s worth looking into.

So why were infants at ICC getting AZT? Weren’t there better solutions? ICC seemed to think so. From their published history: "Early in the epidemic, HIV disease of childhood was considered to be a down-hill course leading to death. But in the late 1980's, before AZT was available, many very ill children admitted to ICC got dramatically better with proper nurturing and high-quality medical and nursing care."

Why didn’t they stick with this program? Was it the government funding? Was it political pressure to get the drug approved for new markets? It certainly wasn’t the effectiveness of the drug. We don’t hear stories in the current AZT/Nevirapine era about "many very ill children" becoming "dramatically better."

So, there were problems at ICC. But they certainly couldn’t force the children to take the drugs, could they?

Well, actually, they could. And they do.

How do they do it? It’s not pleasant to tell. Maybe you don’t want to know. Anyway, if it’s not in the New York Times, maybe it’s not important. But I had to ask.

I talked to ICC’s medical director Dr. Katherine Painter about it. She kindly provided details of the surgery given to children who "can't take" or simply refuse the drugs. As per medical protocol, these children have a tube surgically implanted in their abdomens through which the drugs are easily administered, regardless of the child's wishes. I wrote about it in an article called "The House That AIDS Built" and in a second article called "Orphans On Trial," which was published in the New York Press in July, 2004.

I haven’t seen anything on it in the NY Times. But, of course, the chief writer on HIV at the NY Times is (and has been for over 20 years) a man named Lawrence Altman. And Lawrence Altman can’t write stuff like this, even if he wants to.

You see, Altman is a former graduate of the CDC—the organization that makes the rules for how HIV patients are treated and diagnosed in this country. So, of course, Altman’s hands are tied. "All the News That’s Fit to Print" suddenly has a very clear, very unpleasant meaning.

Next time you see the headline "New AIDS Drugs for Africa" or "Noble Doctors Try New Drugs on Orphans," what will you think? Will you ask yourself what’s behind it? If you want to find out, you’ll have to dig a little.

June 2005: An update by Vera Hassner Sharav of the ALLIANCE FOR HUMAN RESEARCH PROTECTION (AHRP)

The Associated Press reports that an investigation by the U.S. Department of Health and Human Services' Office of Human Research Protections (OHRP) concluded that:
"Columbia University Presbyterian Medical Center in New York, where several foster children were enrolled in drug studies in the 1990s, failed to obtain and evaluate whether it had proper consent, information and safeguards for the foster kids."

OHRP's investigation found that the hospital's "records demonstrate a failure ... to obtain sufficient information regarding such safeguards with respect to the enrollment of wards of the state or foster children," the agency concluded.

In a letter dated May 23, the government cited Columbia Presbyteria with violating rules in at least four AIDS studies involving foster children, including:

Failing to "obtain sufficient information regarding the selection of wards of the state and foster children as research subjects."

Failing to "obtain sufficient information regarding the process for obtaining permission of parents or guardians for wards of the state or foster children."

Failing to have enough information to ensure the selection of patients for the studies was "equitable."

In its letter to the hospital, OHRP noted:
"When some or all of the subjects (e.g., children) are likely to be vulnerable to coercion or undue influence, additional safeguards have been included in the HHS regulations to protect the rights and welfare of these subject."

"Federal rules require researchers to provide independent advocates to foster children in a narrow class of experiments that pose more than a minimal risk and do not hold the likelihood of improved health for the test patients. Those rules also require the researchers to follow any additional safeguards imposed by state and local authorities."

These Federal safeguards prohibiting the use of children in foster care for any but essential experiments intended for their best interest -- and then, only with the consent and on-going monitorin by an independent advocate for each child, were adopted precisely to prevent their abuse and exploitation.

But the foster children enrolled in AIDS drug and vaccine trials -- all of whom were children of color -- were enrolled illegally. The children were denied the minimal protections, in part, because of a culture of arrogance that permeates the medical research community. That culture of lawless disregard for the disadvantaged in the community needs to be changed by Congressional action.

A law is needed to protect children and vulnerable adults from overreaching researchers who seem to think that ethical standards and Federal regulations are a matter for their discretion. A law is needed to make it a criminal offense to use a human being in medical experiments that faile to comply with Federal rules.

Questions remain about the death toll and the adverse events suffered by the children: how many children who were illegally enrolled in phase I and II drug and vaccine expeiments died? Nothing has been reported about the financial stakes in these pediatric AIDS trials.

As acknowledged by AP, The Alliance for Human Research Protection filed the complaint that led to the Federal investigation.

Vera Hassner Sharav

See other recent articles:

pril 23, 2005 -- The city has asked an independent group to determine whether proper procedures were followed when 465 HIV-positive children in foster care were put in clinical drug trials from 1988 to 2001, officials said yesterday. The Administration for Children's Services has contracted with the Vera Institute of Justice, a not-for-profit research organization, to examine whether the required parent or guardian consents were obtained, whether the medical criteria were met and whether ACS correctly monitored the situation.

The Truth about Nevirapine - Stepping over bodies on the way to market
By Liam Scheff

References and Further Reading:

Crippling side effects of Nevirapine and other drugs

"Orphans On Trial." Liam Scheff. New York Press; July 14, 2004.
"Is Academic Medicine For Sale?" Dr. Marcia Angell. New England Journal of Medicine; May 18, 2000.

"Death by Medicine." Gary Null PhD, Carolyn Dean MD ND, et al. Nutrition Institute of America. November, 2003.

"Conflict of Interest?" John McKenzie. ABC News; June 12, 2002.

"AIDS; Words From The Front." Bryan Ellison. Spin. December, 1993.

Support the "Aids Critics Keywords Campaign" idea for action through the internet...

Guinea Pig Kids in AIDS Drugs Trials
Sam Burcher - Institute of Science in Society
The anti-HIV drugs, AZT and nevirapine, are known to be highly toxic and to cause serious side effects. Despite this, they are still being used in clinical trials involving some of the most vulnerable members of society, pregnant women and newborn babies in Africa, and orphans in the United States.

NIH-Sponsored AIDS Drugs Tests on Mothers and Babies
Sam Burcher - Institute of Science in Society
In December 2004 , the Associated Press claimed that the adverse events in Uganda were censored and unknown to President Bush in 2002 when he announced his $500 million plan to push nevirapine across Africa to a million women a year. But before the plan went into effect, The NIH shut down the Ugandan research until the summer of 2003 to review the science and to make the necessary amends. They asked the National Academy of Sciences to investigate the case and spent millions of dollars on improving record keeping and safety monitoring. A top NIH disease official reviewing the case concluded that the use of nevirapine even in single doses could confer instant drug resistance to HIV - positive patients, which would prevent the use of any other available antiretroviral drugs for future treatment. Therefore it was unsuitable as a first drug of choice.

The Trouble with Nevirapine
this is a 230-some pages book about the Aids drug Nevirapine by Anthony Brink, an advocate of the High Court of South Africa and convener and chairman of the Treatment Information Group...

17 July 2005 - The New York Times just covered - I suppose 'attempted to bury' would be a better way to say it - the story on Incarnation Childrens' Center in New York drafting orphans into AIDS drug studies or "experimental treatments" and forcing the kids to take the drugs by surgical feeding tube implants. The story was investigated and exposed by Liam Scheff.

Below is Liam's response to the NY Times.

What can I say? At least the "newspaper of note" has to do a hack job on the story, it's no longer possible to just ignore what is posted in various places on the internet...

Kind regards

Date: Sat, 16 Jul 2005
From: liam scheff
Subject: NY Times "Covers" ICC story - important - please take a minute

NY Times Covers ICC story.. And by Covers - I mean buries.

It's in the Times, so lots of people will skim it.
If you find their reporting lacking in any facts, then please write them a letter at:

The article was written by
Janny Scott and Leslie Kaufman.

They interviewed me, but only used the little bit they needed to make everybody feel good about ignoring the story.

What can you expect? It's the NY Times.

But you can email them a response, if you want to put together a reasonable letter.

My letter can be found here (scroll down the page to number 5)

Liam Scheff comments on the reporting the Front Page Mag did, based on the earlier New York Times article on the exposure of the Incarnation Childrens Center's AIDS drug experimentation on orphans:

More New York Times Bullshit on the AIDS/ICC Scandal

The Times piece is regurgitated by, without a single fact checked.

contact FrontPageMag

or email

Dear Editor,

Your writer's (Ryan O'Donnell's) piece on me and the ICC story is pure garbage,

"The Left's War on Black and Latino Children"

but I'm trying not to hold that against you.

The NY Times, which your writer quotes with reckless abandon, had a reason to exclude most of the important facts in their fictitious and easily-disputed report on the ICC story...

read Liam's whole piece

See also:

Infants exposed to AZT and Lamidovine will get cancer
Two new animal studies have examined the cancer-causing effects of transplacental exposure to AZT in mice and rats and found increased rates of tumors and tumors with gene changes that frequently occur in human cancer. In addition, two human studies are the first to observe the induction of mutations and large scale chromosomal damage in red blood cells of newborns exposed to NRTIs in utero.

More 'Guinea Pig' Kids
An ongoing investigation by the Vera Institute of Justice, has uncovered 59 additional New York City foster care children--between July and September--who may have been used in AIDS drug / vaccine trials in violation of federal regulations. This brings the tentative total number of mostly minority children involved, to 773.

The AIDS Investigation by Liam Scheff
In 2004, I broke open the NIH clinical trial scandal - government researchers using New York City orphans in clinical trials with combinations of highly toxic, speculative drugs.

New York Times - Children Die in Aids Drug Trials, but the Drugs are Fine, Fine, Fine
What can I say that Robert Lifton hasn't written so clearly, and so well already? We are practicing a corrupted medicine. There is a taint of racism running through Aids science. We are over-burdening groups with the permanent and fatal 'Aids' diagnosis, based on faulty technology, and an immovable assumption that we then enforce by the overly-toxic regimens you witness above.

How do we propose to save children by first, giving them a death sentence based on faulty and poly-reactive (poly-diagnostic) tests [HIV Tests - Yes, They Do Not Diagnose Nor Are Specific For Only One Condition];

Then enrolling them with or without permission into drug trials with the most severe toxic effects recorded in a pharmaceutical [Nevirapine].


posted by Sepp Hasslberger on Friday November 5 2004
updated on Friday December 10 2010

URL of this article:


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Readers' Comments

Anti retrovirals are not the only drugs which are deadly. I have a list of about 100 substances which have caused Stevens-Johnson Syndrome (a potentially fatal adverse drug reaction) some of which are over the counter meds such as Advil and paracetemol!

If SJS doesn't kill you, it leaves you with lifelong disablement, pain and disfigurement.

Down here at the tip of Africa, ARVs are a big issue and people are not being educated about the potential risk.

luv from sunny South Africa


Posted by: Sara on November 7, 2004 08:29 AM


Article in the LA Times and comments from Vera Hassner Sharav of AHRP:

LA Times: Researchers Tested AIDS Drugs on Children


On March 10, 2004, The Alliance for Human Research Protection filed a complaint with the FDA and the federal Office of Human Research Protection about a series of AIDS drug experiments conducted on New York City children in foster care. That complaint prompted two separate investigations by the FDA and OHRP which are still on-going.

Articles in The New York Post and a documentary by BBC raised the alarm among the African-American and Latino community in NY-some of who have been protesting weekly in front of Incarnation Children's Center, the site of some of the drug experiments.

The Associated Press AP has just released its investigative report: the problem is a national scandal--the experiments were conducted in "at least seven states -- Illinois, Louisiana, Maryland, New York, North Carolina, Colorado and Texas -- and involved more than four dozen different studies.

AP's investigation found that 13,878 children had been enrolled in pediatric AIDS studies funded by the government since the late 1980s. Of these, officials estimated that 5 percent to 10 percent were in foster care. Their age ranged from infants to late teens.

"More than two dozen Illinois foster children remain in studies today."

Those who conducted the experiments in violation of federal regulations, are supported by taxpayers-thus they have a public responsibility which they violated. The children who were targeted to serve as human drug testing subjects-mostly poor children of color-were not afforded the protection of a personal advocate-as is mandated by federal regulations. (45 Code of Federal Regulations 46.409)

The institutional culture of arrogance is demonstrably in evidence at both medical research centers and government agencies: "Our position is that advocates weren't needed," said Marilyn Castaldi, spokeswoman for Columbia Presbyterian Medical Center in New York.

And officials of NYC Administration of Child Services "defend the decision to enlist foster children en masse, saying there was a crisis in the early 1990s and research provided the best treatment possibilities."

The children are reported to have suffered painful side effects "such as rashes, vomiting and sharp drops in infection-fighting blood cells as they tested antiretroviral drugs to suppress AIDS or other medicines to treat secondary infections."

In one study testing the drug dapsone, "at least 10 children died from a variety of causes, including four from blood poisoning, and researchers said they were unable to determine a safe, useful dosage. They said the deaths didn't appear to be "directly attributable" to dapsone but nonetheless were "disturbing."

"overall mortality while receiving the study drug was significantly higher in the daily dapsone group. This finding remains unexplained," the researchers concluded.

"Another study involving foster children in the 1990s treated children with different combinations of adult antiretroviral drugs. Among 52 children, there were 26 moderate to severe reactions -- nearly all in infants. The side effects included rash, fever and a major drop in infection-fighting white blood cells.

At least three states declined to use children in foster care in medical experiments: Tennessee said its foster care rules generally prohibit enlisting children in such trials. California requires a judge's order. And Wisconsin "has absolutely never allowed, nor would we even consider, any clinical experiments with the children in our foster care system," spokeswoman Stephanie Marquis said.

Not addressed in the AP report is the amount of money that these trials generated for the institutions involved in the experiments.

Vera Hassner Sharav

Posted by: Sepp on May 5, 2005 06:00 PM


Here's a link to a recent article in the Toledo Blade, and a comment sent in by Liam Scheff:

Foster children were helped by medical trials

Foster Children in Clinical Trials? Hell Yuuueah!!!

Or so says the most independent Dr.Mark Kline in a Toledo Blade Editorial.

"Do I regret including these foster children in clinical trials? --No. I had to do something to help them, to extend their lives, which were as precious to me and others in my field as were the lives of those children who had parents to push us to provide them with the most potent treatments available."

Potent is right...

As the good doctor says of early AIDS therapies (AZT): "I and others who treated them saw them die because available treatments offered only partial, short-lived benefits."

Partial benefits - riiight, that's it, that's how it works. Never mind actual data, drug effects, profit margins, hell, never mind research. The story's good enough. You meant well. So, we'll love you for trying.

Bless you and your warm, wonderful worldview, Doc. A few more guys like you and we can all retire to our barracks,, bunks,, ovens,, oh,,,, whatever. I'm sure you know what's best for all of us.

letters to the editor:

Posted by: Sepp on June 2, 2005 11:13 PM


Using children to test drugs on is cruel and heartless!!!

Posted by: Amy Bradford on March 18, 2007 01:20 PM


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The Individual Is Supreme And Finds Its Way Through Intuition


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